宫颈癌临床前模型的研究进展  

Advances in preclinical model of cervical cancer

作　　者：陈元静 刘小凤 李雯 罗仁洁 王丹 张文艳 刘会玲[2] CHEN Yuanjing;LIU Xiaofeng;LI Wen;LUO Renjie;WANG Dan;ZHANG Wenyan;LIU Huiling(The First Clinical Medical College,Gansu University of Traditional Chinese Medicine,Gansu Lanzhou 730000,China;Department of Gynecology,Gansu Provincial Hospital,Gansu Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院妇二科,甘肃兰州730000

出　　处：《现代肿瘤医学》2025年第4期669-675,共7页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:82260557);甘肃省兰州市科技计划项目(编号:2023-ZD-21)。

摘　　要：宫颈癌是继乳腺癌、肺癌和结直肠癌之后,影响全球女性的第四大常见癌症。尽管它是一种可预防的癌症,但高发病率和死亡率都反映出它是一个主要的生殖健康问题。目前,临床宫颈癌患者药物治疗、手术治疗、化学治疗后复发转移率仍然居高不下。动物模型可以模拟宫颈癌发展特征,是研究预防和治疗宫颈癌的重要工具。该文介绍了当前研究较多的三种动物模型:患者来源的异种移植(patient-derived xenografts,PDX)模型、基因工程小鼠(genetically engineered mouse,GEM)模型、类器官模型,并对每种宫颈癌动物模型所使用的小鼠种类、构建方法、研究进展及优缺点进行详细阐述,以期为宫颈癌动物模型的构建提供理论依据。同时预测,多模型的联合应用可使肿瘤研究更加精准与便捷,甚至类器官模型代替普通动物模型将成为一种未来趋势。Cervical cancer is the fourth most common cancer affecting women worldwide after breast cancer,lung cancer and colorectal cancer.Although it is a preventable cancer,the high incidence and mortality rates reflect that it is a major reproductive health problem.At present,the recurrence and metastasis rate of clinical cervical cancer patients after drug treatment,surgical treatment and chemotherapy is still high.Animal model can simulate the development characteristics of cervical cancer and is an important tool for the prevention and treatment of cervical cancer.This paper introduces three animal models that have been widely studied at present,including patient-derived xenografts(PDX)model,genetically engineered mouse(GEM)model and organoid model.The types of mice used in each cervical cancer animal model,construction methods,research progress,advantages and disadvantages were described in detail,in order to provide theoretical basis for the construction of cervical cancer animal model.At the same time,it is predicted that the combined application of multiple models can make tumor research more accurate and convenient,and even organoid models will become a future trend to replace ordinary animal models.

关 键 词：子宫颈癌 患者来源的异种移植模型 基因工程小鼠模型 类器官模型 

分 类 号：R737.33[医药卫生—肿瘤]