CT影像组学在胃癌时空异质性中的研究进展  

Research progress of CT radiomics in spatiotemporal heterogeneity of gastric cancer

作　　者：钟肖雨 王悦玲 刘佳让 范佳绮 徐恬 何思怡 黄奔皓 黄陈 ZHONG Xiaoyu;WANG Yueling;LIU Jiarang;FAN Jiaqi;XU Tian;HE Siyi;HUANG Benhao;HUANG Chen(Department of Gastrointestinal Surgery,Shanghai General Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China;Wuxi School of Medicine,Jiangnan University,Jiangsu Wuxi 214122,China)

机构地区：[1]上海交通大学医学院附属第一人民医院胃肠外科,上海200080 [2]江南大学无锡医学院,江苏无锡214122

出　　处：《现代肿瘤医学》2025年第4期701-711,共11页Journal of Modern Oncology

基　　金：上海交通大学医学院高峰高原计划(编号:20194125)。

摘　　要：胃癌是一种高度异质性的恶性肿瘤。尽管近年来胃癌放化疗和免疫治疗取得了长足进展,但由于高度的肿瘤异质性,胃癌患者的临床获益十分有限。近年来,随着多组学研究和高通量测序技术的发展,越来越多的研究表明时间和空间层面中的胃癌异质性具有重要的临床意义,有望为胃癌早期诊治提供指标和方法。新兴的CT影像组学可以提供多阶段、多部位的胃癌影像学信息,通过肿瘤分割、特征提取和模型建立,有望为胃癌诊治提供新的、无创、可靠、高效的指标。因此,该文从时空异质性角度思考、归纳胃癌异质性研究的现状,阐述CT影像组学在胃癌时空异质性研究中的发展态势,以期深化对胃癌时空异质性的理解,推进胃癌精准医疗,并最终改善胃癌患者的生存预后。Gastric cancer is a highly heterogeneous malignant tumor.Despite significant progress in radiotherapy,chemotherapy,and immunotherapy for gastric cancer in recent years,the clinical benefits for gastric cancer patients are limited due to high tumor heterogeneity.In recent years,with the development of multiomics research and high-throughput sequencing technology,more and more studies have shown that the heterogeneity of gastric cancer at the temporal and spatial levels has important clinical significance,which is expected to provide indicators and methods for early diagnosis and treatment of gastric cancer.The emerging CT radiomics can provide multi-stage and multi-site imaging information for gastric cancer.Through tumor segmentation,feature extraction,and model establishment,it is expected to provide new,non-invasive,reliable,and efficient indicators for the diagnosis and treatment of gastric cancer.Therefore,this review considers and summarizes the current status of research on gastric cancer heterogeneity from the perspective of spatiotemporal heterogeneity,elaborates on the development trend of CT radiomics in the study of gastric cancer spatiotemporal heterogeneity,in order to deepen the understanding of gastric cancer spatiotemporal heterogeneity,promote precise medical treatment of gastric cancer,and ultimately improve the survival and prognosis of gastric cancer patients.

关 键 词：CT 影像组学 胃癌 肿瘤异质性 

分 类 号：R735.2[医药卫生—肿瘤]