探讨3D腹腔镜全胃切除胃癌根治术治疗进展期胃癌的临床价值  

Clinical value of 3D laparoscopic total gastrectomy for radical gastric cancer treatment of progressive gastric cancer

作　　者：李永坤[1] 彭朝阳[1] 贾亚鹏 王虔 刘耿[1] Li Yong-kun;Peng Chao-yang;Jia Ya-peng;Wang Qian;Liu Geng(Department of General Surgery,Nanyang Medical Vocational School First Affiliated Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳医学高等专科学校第一附属医院普通外科,河南南阳473000

出　　处：《四川生理科学杂志》2025年第3期489-491,共3页

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20220807)。

摘　　要：目的:探讨3D腹腔镜全胃切除胃癌根治术治疗进展期胃癌的临床价值。方法:回顾性分析本院2022年01月至2024年01月期间医治的104例进展性胃癌患者资料,依据不同手术方法分为研究组(n=55)和对照组(n=49),前者行3D腹腔镜全胃切除胃癌根治术,后者行普通腹腔镜辅助全胃切除胃癌根治术。比较两组围术期指标,并于术前、术后1 w采用酶联免疫法检测内毒素(Endothelin^(-1),ET)、二胺氧化酶(Diamine oxidase,DAO)、闭锁小带蛋白(Zonula Occludens-1,ZO-1)、白细胞介素-4(Interleukin-4,IL-4)、C反应蛋白(C-reactive protein,CRP)、白细胞介素-8(Interleukin-8,IL-8)水平,统计并比较两组并发症。结果:研究组肠鸣恢复时间、首次排气时间、首次下床时间、住院时间短于对照组,出血量少于对照组,胃肠功能、炎性反应指标低于对照组(P<0.05);两组并发症发生率相比(1.81%vs 8.16%),差异无统计学意义(P>0.05)。结论:3D腹腔镜全胃切除胃癌根治术能促进肠胃功能快速恢复,减轻机体炎性反应,安全性较好。Objective:To explore the clinical value of 3D laparoscopic total gastrectomy to treat advanced gastric cancer.Method:Retrospective analysis of the data of 104 patients with progressive gastric cancer treated in our hospital from January 2022 to January 2024.They were divided into a study group(n=55)and a control group(n=49)according to different surgical methods.The former underwent 3D laparoscopic total gastrectomy for radical resection of gastric cancer,while the latter underwent conventional laparoscopic-assisted total gastrectomy for radical resection of gastric cancer.The perioperative indicators of the two groups were compared,and the levels of endothelin^(-1)(ET),diamine oxidase(DAO),zonula occludens-1(ZO-1),interleukin-4(IL-4),C-reactive protein(CRP),and interleukin-8(IL-8)were detected by enzyme-linked immunosorbent assay before and 1 week after surgery.The complications of the two groups were statistically compared.Results:The recovery time of bowel sounds,the first time of exhaust,the first time of getting out of bed,and the length of hospital stay in the study group were shorter than those in the control group,and the amount of bleeding was less than that in the control group.The gastrointestinal function and inflammatory response indicators were lower than those in the control group(P<0.05).The incidence of complications in the two groups was compared(1.81%vs 8.16%),and the difference was not statistically significant(P>0.05).Conclusion:3D laparoscopic total gastrectomy for radical resection of gastric cancer can promote the rapid recovery of gastrointestinal function,reduce the inflammatory response of the body,and have good safety.

关 键 词：进展期胃癌 胃癌根治术 胃肠功能 出血量 3D腹腔镜 

分 类 号：R73[医药卫生—肿瘤]