大分割调强放疗对乳腺癌术后患者的影响  

The effect of macrodissection intensity-modulated radiotherapy on postoperative breast cancer patients

作　　者：张瑞 张民杰 冯高青 孙慧娜 姜清芳 吴娅丽 Zhang Rui;Zhang Min-jie;Feng Gao-qing;Sun Hui-na;Jiang Qing-fang;Wu Ya-li(Department of Radiotherapy,Kaifeng Cancer Hospital,Kaifeng 475003,Henan,China)

机构地区：[1]开封市肿瘤医院放疗科一病区,河南开封475003

出　　处：《四川生理科学杂志》2025年第3期611-614,共4页

摘　　要：目的:分析大分割调强放疗对乳腺癌术后患者的影响。方法:选取2021年12月至2023年12月我院乳腺癌术后患者60例,随机分为观察组和对照组(n=30),分别采用常规放疗或大分割调强放疗。治疗前、治疗1 m后通过酶联吸附试验法检测血清β2-微球蛋白(Serumβ2-microglobulin,β2-MG)、癌胚抗原(Carcinoembryonic antigen,CEA)、甲胎蛋白(Alpha-fetoprotein,AFP)、白细胞介素-6(Interleukin-6,IL-6)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)水平;以流式细胞术检测分化族4(Differentiated Clan 4,CD4^(+))、分化族8(Differentiated Clan 8,CD8^(+))水平。结果:与治疗前相比,各治疗组β2-MG、CEA、AFP、IL-6、TNF-α、CD8^(+)水平均明显降低,CD4^(+)水平明显升高(P<0.05),其中观察组更为显著(P<0.05);观察组不良反应20.00%(6/30)较对照组46.67%(14/30)低(χ^(2)=4.800,P<0.05);观察组局部控制率96.67%(29/30)较对照组73.33%(22/30)高(χ^(2)=4.706,P<0.05);与治疗前相比,各治疗组FACT-B评分均明显升高(P<0.05),其中观察组更为显著(P<0.05)。结论:大分割调强放疗治疗乳腺癌术后患者可降低肿瘤标志物水平,减少不良反应,改善预后,提高生活质量。Objective:To analyze the effect of large-split intensity-modulated radiotherapy on postoperative breast cancer patients.Methods:From December 2021 to December 2023,60 patients with postoperative breast cancer in our hospital were randomly divided into the observation group and the control group(n=30),and the conventional radiotherapy or the large fraction intensity modulated radiotherapy were used,respectively.Serumβ2-microglobulin(β2-MG),carcinoembryonic antigen(CEA),alpha fetoprotein(AFP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)levels were detected by enzyme-linked immunosorbent assay before and 1 month after treatment.The levels of differentiated Clan 4(CD4^(+))and differentiated Clan 8(CD8^(+))were measured by flow cytometry.Result:After treatment,the levels ofβ2-MG,CEA,AFP,IL-6,TNF-α,and CD8^(+)in each group were significantly reduced,while the level of CD4^(+)was significantly increased(P<0.05),with the observation group being more significant(P<0.05).The incidence of adverse reactions in the observation group was 20.00%(6/30),which was lower than that in the control group(46.67%(14/30),χ^(2)=4.800,P<0.05).The local control rate of the observation group was 96.67%(29/30),which was higher than the control group(73.33%(22/30),χ^(2)=4.706,P<0.05).Compared with before treatment,the FACT-B scores in all treatment groups were significantly increased(P<0.05),with the observation group showing a more significant increase(P<0.05).Conclusion:Large fraction intensity modulated radiotherapy for breast cancer patients after surgery can reduce the level of tumor markers,reduce adverse reactions,improve the prognosis and improve the quality of life.

关 键 词：乳腺癌 根治术后 大分割调强放疗 

分 类 号：R73[医药卫生—肿瘤]