雷尼替丁序贯奥美拉唑三联疗法治疗Hp阳性消化性溃疡患者疗效及血清CRP、IL-6的影响  

Curative effect of sequential triple therapy with ranitidine and omeprazole and its influences on serum CRP and IL-6 in patients with Hp-positive peptic ulcer

作　　者：高玉志 Gao Yu-zhi(Department of Emergency,Nancheng County People's Hospital,Fuzhou 344700,Jiangxi,China)

机构地区：[1]南城县人民医院急诊科,江西抚州344700

出　　处：《四川生理科学杂志》2025年第3期667-669,共3页

摘　　要：目的:雷尼替丁序贯奥美拉唑三联治疗幽门螺杆菌阳性(Helicobacter pylori,Hp)消化性溃疡患者疗效及血清C-反应蛋白(C-reactive protein,CRP)、白细胞介素-6(Interleukin-6,IL-6)的影响。方法:以2023年1月至2024年1月在南城县人民医院住院收治的Hp阳性消化性溃疡患者60例为研究对象,按随机数表法将其分为对照组和序贯组,每组患者各30例。对照组采用奥美拉唑+克拉霉素+阿莫西林三联疗法治疗,序贯组克拉霉素和阿莫西林用法同对照组,其中奥美拉唑服用1 w后更换为雷尼替丁治疗,两组均持续治疗3 w。于治疗3 w后比较两组临床疗效、治疗前和治疗3w后比较血清炎性因子水平、Hp根除率、复发率、不良反应发生率。结果:经过3 w治疗后,序贯组总有效率为90.00%,对照组总有效率为86.67%,两组临床疗效比较,差异无统计学意义(P>0.05);治疗后,序贯组的血清白细胞介素-6、C反应蛋白、血清降钙素原水平,与对照组相比降低(P<0.05);治疗3w后,序贯组的Hp根除率96.67%,对照组根除率93.33%,两组比较,差异无统计学意义(P>0.05),序贯组复发率为6.67%低于对照组复发率30.00%(P<0.05);序贯组和对照组的不良反应相似,无明显差异(P>0.05)。结论:雷尼替丁序贯奥美拉唑治疗Hp阳性消化性溃疡能减轻患者的炎性因子水平,降低复发率。Objective:To explore the curative effect of sequential triple therapy with ranitidine and omeprazole and its influences on serum C-reactive protein(CRP)and interleukin-6(IL-6)in patients with Helicobacter pylori(Hp)-positive peptic ulcer.Methods:60 patients with Hp-positive peptic ulcer admitted to Nancheng County People's Hospital from January 2023 to January 2024 were enrolled as the research objects.According to random number table method,they were divided into control group and sequential group,30 cases in each group.The control group were treated with omeprazole+clarithromycin+amoxicillin triple therapy.The treatment of clarithromycin and amoxicillin in sequential group were the same as that of the control group,and the treatment of omeprazole was changed to ranitidine after one week.All patients were continuously treated for 3 weeks.The clinical curative effect after 3 weeks of treatment,serum inflammatory factors,Hp clearance rate,recurrence rate and incidence of adverse reactions before treatment and after 3 weeks of treatment were compared between the two groups.Results:After 3 weeks of treatment,total response rates in sequential group and control group were 90.00%and 86.67%,and there was no significant difference in clinical curative effect between the two groups(P>0.05).After treatment,levels of serum interleukin-6,C-reactive protein and procalcitonin in sequential group were lower than those in control group(P<0.05).After 3 weeks of treatment,there was no significant difference in Hp clearance rate between sequential group and control group(96.67%vs 93.33%,P>0.05).The recurrence rate in sequential group was lower than that in control group(6.67%vs 30.00%,P<0.05).The adverse reactions in sequential group and control group were similar(P>0.05).Conclusion:Ranitidine combined with omeprazole can reduce levels of inflammatory factors and recurrence rate in patients with Hp-positive peptic ulcer.

关 键 词：雷尼替丁 奥美拉唑 三联疗法 幽门螺旋杆菌 消化性溃疡 C-反应蛋白 白细胞介素-6 

分 类 号：R57[医药卫生—消化系统]