Mild diarrhea leading to tacrolimus toxicity in an immunocompromised patient with suspected community-acquired pneumonia:a case report  

作　　者：Xueying Chen Jianbo Ding Jiali Zhang Hongyan Jiang Haibin Dai Lingyan Yu 

机构地区：[1]Department of Pharmacy,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China [2]Department of Emergency Medicine,the Second Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310009,China

出　　处：《World Journal of Emergency Medicine》2025年第2期174-176,共3页世界急诊医学杂志(英文)

基　　金：supported by the Clinical Research Foundation of Zhejiang Provincial Medical Association (2020ZYC-A113)。

摘　　要：Tacrolimus (TAC) is increasingly used for immunosuppression in organ transplantation,dermatomyositis/polymyositis,and myasthenia gravis(MG) patients.^([1]) TAC has a narrow therapeutic window with overexposure leading to acute and chronic forms of adverse reactions (ADRs).After oral administration,TAC is predominantly absorbed in the duodenum and jejunum and has highly variable pharmacokinetics,particularly when diarrhea occurs.^([2,3]) Few data has been published on TAC overexposure following mild diarrhea.Mild diarrhea is relatively common and often unreported,which can easily be overlooked by physicians,especially in the emergency department.Here,we report the occurrence of serious ADRs to TAC after mild diarrhea in a MG patient with community-acquired pneumonia(CAP),including nephrotoxicity,metabolic abnormalities and severe immunosuppression.

关 键 词：DIARRHEA PNEUMONIA GRAVIS 

分 类 号：R563.1[医药卫生—呼吸系统]