supported by the Clinical Research Foundation of Zhejiang Provincial Medical Association (2020ZYC-A113)。
Tacrolimus (TAC) is increasingly used for immunosuppression in organ transplantation,dermatomyositis/polymyositis,and myasthenia gravis(MG) patients.^([1]) TAC has a narrow therapeutic window with overexposure leading...
funded by the National Key R&D Program of China(to Z.Z.,2021YFA1302300);the National Natural Science Foundation of China(to Z.Z.,32171201);the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(to C.S.,T2321001);the STI2030-Major Projects(to Yixiao Z.,2022ZD0207400);the Basic Research Pioneer Project of the Science and Technology Commission of Shanghai Municipality(STCSM,to Yixiao Z.);The study was also supported in part by the Center for Life Sciences(CLS),School of Life Sciences(SLS)of Peking University,the State Key Laboratory of Membrane Biology of China,the Frontier Innovation Fund of Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies(to Z.Z.),and ALSAC(to C.-H.L.).
Dear Editor,Acetylcholine(ACh)is an excitatory neurotransmitter with a wide variety of functions.In the central nervous system,ACh helps regulate memory,motivation,arousal,and attention.ACh controls muscle contraction...
This study was supported by the Public Welfare Scientific Research Project of China(No.201402012);the National Natural Science Foundation of China(No.81974255).
Recombination-activating gene 1(RAG1)mutations in humans vary in residual recombination activity and result in heterogeneous clinical phenotypes[1,2].In recent years,RAG deficiency with a milder clinical course and de...
Objective To observe the curative effect of needle roller combined with Qiangli Yiqi Prescription(QLYQP)on myasthenia gravis(MG)patients with Pi-qi deficiency and on the levels of inflammatory factors such as interleu...
Objective To determine the correlation between the titer of anti-muscle-specific tyrosine kinase(anti-MuSK)antibodies(Abs)and the severity and prognosis of Musk-associated myasthenia gravis(Musk-MG).Methods A total of...
Objective To study the clinical characteristics of pregnant patients with myasthenia gravis (MG) and the influence of MG on pregnancy.Methods A retrospective study was conducted,including 28 MG patients with 38 pregna...
supported by grants from ZonMw,“Goed Gebruik Geneesmiddelen”(project number 836031008);the Zorgverzekeraars Nederland and Dutch Kidney Foundation(13OCA27 COMBAT Consortium).
Dear Editors,Eculizumab is a therapeutic complement C5 inhibitor approved for the treatment of atypical hemolytic uremic syndrome(aHUS),paroxysmal nocturnal proteinuria(PNH),generalized myasthenia gravis and neuromyel...
We report four observations of myasthenia gravis associated with other autoimmune diseases. Myasthenia gravis can be associated with all autoimmune diseases with a predominance of dysthyroidism. Among the autoimmune d...
The anaesthetic management of the pregnant woman with myasthenia gravis (MG) is very challenging to the anaesthesiologist. This situation becomes exaggerated in emergency settings in a low resource area, especially wh...
Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper and lower neurons with no effective cure. Electrophysiological studies have found decremental responses d...