Structural insights into VAChT neurotransmitter recognition and inhibition  

作　　者：Yang Zhang Fei Dai Nanhao Chen Dong Zhou Chia-Hsueh Lee Chen Song Yixiao Zhang Zhe Zhang 

机构地区：[1]State Key Laboratory of Membrane Biology,School of Life Sciences,Peking University,Beijing,China [2]Interdisciplinary Research Center on Biology and Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,China [3]State Key Laboratory of Chemical Biology,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai,China [4]Center for Quantitative Biology,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,China [5]Center for Life Sciences,Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,China [6]Department of Structural Biology,St.Jude Children’s Research Hospital,Memphis,TN,USA

出　　处：《Cell Research》2024年第9期665-668,共4页细胞研究（英文版）

基　　金：funded by the National Key R&D Program of China(to Z.Z.,2021YFA1302300);the National Natural Science Foundation of China(to Z.Z.,32171201);the Science Fund for Creative Research Groups of the National Natural Science Foundation of China(to C.S.,T2321001);the STI2030-Major Projects(to Yixiao Z.,2022ZD0207400);the Basic Research Pioneer Project of the Science and Technology Commission of Shanghai Municipality(STCSM,to Yixiao Z.);The study was also supported in part by the Center for Life Sciences(CLS),School of Life Sciences(SLS)of Peking University,the State Key Laboratory of Membrane Biology of China,the Frontier Innovation Fund of Peking University Chengdu Academy for Advanced Interdisciplinary Biotechnologies(to Z.Z.),and ALSAC(to C.-H.L.).

摘　　要：Dear Editor,Acetylcholine(ACh)is an excitatory neurotransmitter with a wide variety of functions.In the central nervous system,ACh helps regulate memory,motivation,arousal,and attention.ACh controls muscle contraction,blood pressure,intestinal peristalsis,and glandular secretion in the peripheral nervous system.Decreased ACh signaling is strongly related to multiple pathological conditions,such as Alzheimer’s disease(AD),Lambert–Eaton myasthenic syndrome,and myasthenia gravis.

关 键 词：GRAVIS ALZHEIMER MYASTHENIA 

分 类 号：R74[医药卫生—神经病学与精神病学]