基于分子标志物的支持方案在老年胶质瘤手术患者中的应用  

Application of molecular biomarker-based support protocol in elderly glioma patients undergoing surgery

作　　者：韩小菲 杜文众[1] Han Xiaofei;Du Wenzhong(Department of Operating Room,the First Affiliated Hospital of Harbin Medical University,Harbin 150001)

机构地区：[1]哈尔滨医科大学附属第一医院中心手术室,哈尔滨150001

出　　处：《国际老年医学杂志》2025年第2期169-173,共5页International Journal of Geriatrics

基　　金：黑龙江省重点研发计划指导类项目(GZ20210157)。

摘　　要：目的探讨基于分子标志物的支持方案在老年胶质瘤手术患者中的应用效果。方法选取2022年1月-2024年1月哈尔滨医科大学附属第一医院收治的120例老年胶质瘤手术患者作为研究对象,按照随机数字表法分为两组,各60例。对照组采用常规治疗支持方案,观察组采用基于分子标志物的支持方案,比较两组术后恢复情况、并发症发生情况及生活质量。结果观察组术后住院时间、切口愈合时间、术后首次进食时间及术后首次进水时间均短于对照组,住院总费用及术后3 d血清白蛋白水平高于对照组,术后3 h内呕吐次数、术后3 d的疼痛评分均低于对照组,术后并发症总发生率低于对照组,观察组术后3个月的生活质量评分高于对照组,差异均有统计学意义(P<0.05)。结论基于分子标志物的支持方案在老年胶质瘤手术患者中可更好地促进患者术后康复,降低并发症的发生风险,提高生活质量,但所花费用也相对较高。Objective To explore the efficacy of a molecular biomarker-based support protocol in elderly glioma patients undergoing surgery.Methods A total of 120 elderly patients with glioma who underwent surgery in the First Affiliated Hospital of Harbin Medical University from January 2022 to January 2024 were selected as the study subjects,and they were divided into two groups according to the random number table,with 60 cases in each group.Routine treatment support program was used in the control group,and molecular marker-based support program was used in the observation group.Postoperative recovery,complications and quality of life were compared between the two groups.Results The postoperative hospital stay,incision healing time,first feeding time and first water intake time in observation group were shorter than those in control group,the total cost of hospitalization and serum albumin level at 3 d after operation were higher than that in control group,the vomiting frequency at 3 h after operation,pain score at 3 d after operation were lower than those in control group,the total incidence rate of postoperative complications was lower than that in control group,the quality of life score at 3 months after operation in observation group was higher than that in control group,and the differences had statistical significance(P<0.05).Conclusion A molecular biomarker-based support protocol can better promote postoperative recovery,reduce the risk of complications,and improve the quality of life in elderly glioma patients undergoing surgery,but it is also relatively expensive.

关 键 词：胶质瘤 分子标志物 手术 支持方案 并发症 生活质量 

分 类 号：R73[医药卫生—肿瘤]