Nine-fold variation of risk of advanced colorectal neoplasms according to smoking and polygenic risk score:Results from a cross-sectional study in a large screening colonoscopy cohort  

作　　者：Ruojin Fu Xuechen Chen Tobias Niedermaier Teresa Seum Michael Hoffmeister Hermann Brenner 

机构地区：[1]Division of Clinical Epidemiology and Aging Research,German Cancer Research Center(DKFZ),Heidelberg,Germany [2]Medical Faculty Heidelberg,Heidelberg University,Heidelberg,Germany [3]College of Pharmacy,Jinan University,Guangdong,P.R.China [4]German Cancer Consortium(DKTK),German Cancer Research Center(DKFZ),Heidelberg,Germany

出　　处：《Cancer Communications》2024年第12期1414-1417,共4页癌症通讯(英文)

基　　金：partly supported by grants from the German Research Council(DFG,grant No.BR1704/16-1);the Federal Ministry of Education and Research(BMBF,grant No.01GL1712);the German Cancer Aid(grant No.70113330).

摘　　要：Colorectal cancer(CRC)is the third most common cancer and the second most common cause of cancer-related death globally[1].The slow progression through the adenoma-carcinoma sequence provides great opportunities for prevention by lifestyle intervention and screening[2].Smoking has been demonstrated to be associated with an increased risk of CRC and an even much stronger increased risk of CRC precursors in a dose-response manner[3,4].

关 键 词：NEOPLASMS prevention colorectal 

分 类 号：R73[医药卫生—肿瘤]