Taurine drives body protein renewal and accretion in beef steers  

作　　者：Shuo Zhang Jinming Hu Yufeng Liu Xu Shen Cheng Liu Long Cheng Mengmeng Li Guangyong Zhao 

机构地区：[1]State Key Laboratory of Animal Nutrition and Feeding,College of Animal Science and Technology,China Agricultural University,Beijing 100193,China

出　　处：《Animal Nutrition》2024年第4期1-12,共12页动物营养(英文版)

基　　金：supported by National Natural Science Foundation of China(grant no.32172748)。

摘　　要：The aims of the present study were to investigate the effects of dietary supplementation with rumenprotected taurine(RPT)on the whole-body protein turnover,the plasma metabolomics,and the whole blood cell transcriptomics in steers.Eight steers,averaging 220±3.26 kg of liveweight,were allocated in a replicate 4×4 Latin square design.The experimental treatments consisted of four levels of RPT supplementation:0,25,50,and 75 g RPT per day,added to a basal diet.The results showed that supplementation with RPT linearly decreased the fecal nitrogen(N)excretion(P=0.001)and the 15N fractional recovery rate(P=0.047),while it linearly increased the urinary excretion of taurine(P=0.045)as well as the average daily weight gain(P=0.003),the protein synthesis(P<0.001),the protein degradation(P<0.001)and the whole-body protein turnover(P<0.001).Supplementation with RPT linearly increased the plasma concentrations of growth hormone(P=0.005)and quadratically affected the plasma concentration of insulin-like growth factor-1(P=0.013),and it linearly decreased the plasma concentration of albumin(P=0.022).Supplementation with RPT altered the whole blood cell mRNA expression and upregulated the expressions of the marker genes,including RPS6KB1,PRSS42,COL1A2,ENSBTAG00000013055 and ENSBTAG00000038159 which are related to protein metabolism.The plasma metabolomics profiling indicated that supplementation with RPT upregulated the plasma concentrations of taurine,lysine and methionine.The experiment revealed the impact and the mechanisms of taurine on driving whole-body protein turnover and protein accretion in steers.Two novel marker genes which could be related to body protein degradation in steers were identified.

关 键 词：TAURINE Whole-body protein turnover Nitrogen metabolism Plasma metabolome Whole-blood cell transcriptome 

分 类 号：R73[医药卫生—肿瘤]