Maternal probiotic mixture supplementation optimizes the gut microbiota structure of offspring piglets through the gut-breast axis  

作　　者：Ting Hu Zhiguan Song Lan Yang Keyuan Chen Yi Wu Fei Xie Jiufeng Wang Guiyan Yang Yaohong Zhu 

机构地区：[1]College of Veterinary Medicine,China Agricultural University,Beijing 100193,China [2]Sanya Institute of China Agricultural University,Sanya 572025,China [3]Animal Disease Prevention and Control Center of Shanxi Province,Taiyuan 030027,China [4]Beijing Da Bei Nong Science and Technology Group Co.,Ltd.,Beijing 100192,China

出　　处：《Animal Nutrition》2024年第4期386-400,共15页动物营养(英文版)

基　　金：supported by the National Natural Science Foundation of China(Project No.32002351 and 31873034);the Hainan Province Science and Technology Special Fund(Project No.ZDYF2023XDNY038);the National Key R&D Program of China(Project No.2023YFC3404301 and 2023YFD1801100).

摘　　要：Delivery and weaning are major stressful events in sows and piglets,adversely affecting production and growth performance and causing economic losses to swine farms.Probiotics as safe antibiotic alternatives have great potential for use across all stages of livestock farming.Here,18 pregnant sows from clinical farms randomly were divided into two groups:one fed a basal diet(CON group)and the other fed a basal diet plus a probiotic mixture CBB-mix(containing 1×10^(12) CFU/g of Lactobacillus johnsonii[CJ21],1×10^(9) CFU/g of Bacillus subtilis[BS15],and 1×10^(9) CFU/g of Bacillus licheniformis[BL21]),for 20 days before delivery.The effects of maternal CBB-mix supplementation on sow colostrum metabolome and offspring piglets'clinical performance,immune status,and gut microbiota were investigated.Additionally,177 piglets were randomly divided into 4 groups,including CC group(piglets and sows fed a basal diet,n=40 from 5 litters),CP group(piglets fed the basal diet plus CBB-mix and sows fed the basal diet,n=38 from 4 litters),PC group(piglets fed the basal diet and sows fed the basal diet plus CBB-mix,n=50 from 4 litters),and PP group(both piglets and sows fed the basal diet plus CBB-mix,n=49 from 5 litters).Among that,CP and PP groups were added CBB-mix in the creep feed from 11 days of age for 18 days to study the direct effects of CBB-mix on the growth performance of piglets.Maternal CBB-mix supplementation improved sow production performance,including litter size at birth and litter weight at birth(P<0.05).Piglets born from CBB-mix-fed sows exhibited increased litter size at weaning and reduced diarrhea incidence from 1 to 10 days of age(P<0.05).Additionally,systemic immune status and antioxidant capabilities were improved in both sows and piglets.Maternal CBB-mix supplementation reconstituted the gut microbiota structure and increased the Sobs index and Shannon index of fecal microbiota in both sows and piglets(P<0.05).The relative abundance of Firmicutes and Clostridium_sensu_stricro_1 in sow feces was decreas

关 键 词：Probiotic mixture Gut microbiota Colostrum metabolome Gutebreast axis SOW PIGLET 

分 类 号：R57[医药卫生—消化系统]