关于自限性癫痫伴中央颞叶棘波患儿认知功能与核磁共振弥散张量成像关系的探寻  

Exploring the relationship between cognitive function and magnetic resonance diffusion tensor imaging in children with self-limited epilepsy with centrotemporal spikes

作　　者：徐媛琴 冯涛[1] 吴敏[1] XU Yuanqin;FENG Tao;WU Min(Department of Neurology,The Second Afiliated Hospital of Baotou Medical College,Baotou 014030,China)

机构地区：[1]包头医学院第二附属医院神经内科,包头014030

出　　处：《癫痫杂志》2025年第2期114-120,共7页Journal of Epilepsy

基　　金：包头市卫生健康科技计划项目(wsjkkj023);包头市卫生健康委科技计划项目(wsjkwkj011)。

摘　　要：目的探寻自限性癫痫伴中央颞叶棘波(Self-limited epilepsy with central-temporal spike waves,SelECTS)患儿的认知功能与核磁共振弥散张量成像(diffusion tensor imagine,DTI)的相关性。方法选取2020年6月—2022年12月在包头医学院第二附属医院就诊的28例SelECTS患儿作为SelECTS组,并选取28例年龄及性别大致相当的健康组作为对照组,采用《韦氏儿童智力量表测验手册》对其进行认知功能检测。并对SelECTS组进行头颅DTI检查,最终将韦氏儿童智力量表的测验结果与DTI值结合并进行相关性比较分析。结果SelECTS组患儿认知功能上存在不同程度的缺陷,总智商和言语智商与对照组相比得分较低(P<0.05),包括分类、言语理解因子、木块图、知识、领悟的测验得分均低于对照组(P<0.05);SelECTS患儿DTI各感兴趣脑区存在着微观结构改变,差异具有统计学意义(P<0.05);其微观结构改变与多项认知功能测验结果之间存在相关性。结论在认知功能上SelECTS组患儿存在一定程度缺陷;且脑白质存在着隐匿性损伤,其认知功能与部分脑区损害存在相关性。Objective To explore the correlation between cognitive function and diffusion tensor imaging(DTI)in children with self-limited epilepsy with centrotemporal spikes(SelECTS).MethodsA total of 28 children with SelECTS who visited our hospital from June 2020 to December 2022 were selected as the SelECTS group.An additional 28 healthy children of similar age and gender were selected as the control group.Cognitive function was assessed using the Wechsler Intelligence Scale for Children(WISC).The SelECTS group also underwent cranial DTI.The results of the WISC were then combined with DTI values for correlation analysis.Results Children in the SelECTS group exhibited varying degrees of cognitive deficits.Their full-scale IQ and verbal IQ were significantly lower than those of the control group(P<0.05).Specific cognitive domains,including classification,verbal comprehension,block design,knowledge,and comprehension,also showed significantly lower scores compared to the control group(P<0.05).DTI revealed significant microstructural changes in multiple regions of interest in the SelECTS group(P<0.05),and these changes were correlated with the results of several cognitive function tests.Conclusion nChildren with SelECTS have certain cognitive deficits.There is evidence of occult damage in brain white matter,and cognitive function is correlated with damage in specific brain regions.

关 键 词：自限性癫痫 核磁共振成像 认知功能 弥散张量成像 

分 类 号：R74[医药卫生—神经病学与精神病学]