儿童癫痫手术后停药复发的风险研究进展  

Research progress of risk factors for recurrence of drug withdrawal after epilepsy surgery in children

作　　者：袁庆庆 操德智[1] YUAN Qingqing;CAO Dezhi(Department of Neurology,Shenzhen Children's Hospital,Shenzhen 518038,China)

机构地区：[1]深圳市儿童医院神经内科,深圳518038

出　　处：《癫痫杂志》2025年第2期144-148,共5页Journal of Epilepsy

基　　金：深圳市儿童医院高水平医院:疑难疾病精准诊治攻关项目(LCYJ2022094)。

摘　　要：癫痫是儿童最常见神经系统疾病之一,约2/3的患者在经过药物治疗后可实现癫痫无发作,但仍有一部分药物难治性癫痫需要进行手术治疗,癫痫外科手术包括切除性手术、离断性手术和姑息性手术等,手术可使30%~40%药物难治性癫痫得到充分控制。对于癫痫术后完全无发作的病例,临床医生通常选择在癫痫手术后癫痫无发作1~2年后停用抗癫痫发作药物,但关于儿童癫痫患者手术后是否停药、多久停药、停药时机等一直存在争议,尚缺乏统一的指南。本文将对儿童癫痫患者手术后停药复发的风险进行综合分析和总结。Epilepsy is one of the most common neurological diseases in children,about 2/3 can be seizure-free after anti-seizure medications(ASMs)treatment,but there are still some drug-resistant epilepsy(DRE)need surgical treatment,epilepsy surgery including excision surgery,dissociation surgery and palliative surgery,surgery can make 30%~40%DRE fully controlled.Clinicians usually choose to discontinue ASMs after seizure-free for 1 to 2 years after epilepsy surgery,but there has been controversy about whether to discontinue ASMs after surgery in children with epilepsy,how long to discontinue ASMs,the timing of ASMs withdrawal,and there is still a lack of unified guidelines.This article will comprehensively analyze and summarize the risk of recurrence after ASMs withdrawal in children with epilepsy.

关 键 词：癫痫 手术治疗 停药 复发 危险因素 

分 类 号：R726.5[医药卫生—儿科]