磁共振引导聚焦超声治疗药物难治性癫痫的研究进展  

Research progress on magnetic resonance guided focused ultrasound therapy for drugresistant epilepsy

作　　者：宋婷婷[1] 贾春岚 赵月 王淇 慕洁 SONG Tingting;JIA Chunlan;ZHAO Yue;WANG Qi;MU Jie(West China Xiamen Hospital of Sichuan University,Department of Neurology,Xiamen 361000,China;West China Xiamen Hospital of Sichuan University,Center for Neurological Function Test and Neuromodulation,Xiamen 361000,China;West China Hospital,Sichuan University,Department of Neurology,Chengdu 610000,China)

机构地区：[1]四川大学华西厦门医院(研究院)神经内科,厦门361000 [2]四川大学华西厦门医院(研究院)神经功能检测与调控中心,厦门361000 [3]四川大学华西医院神经内科,成都610000

出　　处：《癫痫杂志》2025年第2期163-167,共5页Journal of Epilepsy

摘　　要：磁共振引导聚焦超声(magnetic resonance-guided focused ultrasound,MRgFUS)是一种新兴的治疗性超声技术,该技术结合了磁共振成像的精准定位能力和聚焦超声(focused ultrasound,FUS)的非侵入性治疗特性,可精准作用于脑深部靶点,通过消融病变组织、调节大脑神经活动、打开血脑屏障等机制治疗特发性震颤、帕金森病、慢性神经痛等多种中枢神经系统疾病,但其对药物难治性癫痫(drug refractory epilepsy,DRE)治疗的有效性及安全性仍在研究中,因此对MRgFUS在DRE治疗中的应用进展进行综述。Magnetic resonance-guided focused ultrasound(MRgFUS)is an emerging therapeutic ultrasound modality that integrates the precise localization capabilities of magnetic resonance imaging with the non-invasive therapeutic properties of focused ultrasound(FUS).This technology enables accurate targeting of deep brain structures and facilitates the treatment of various central nervous system disorders,including essential tremor,Parkinson's disease,and chronic neuropathic pain,through mechanisms such as ablation of diseased tissue,modulation of neural activity,and disruption of the blood-brain barrier.However,its efficacy and safety in the treatment of drug-resistant epilepsy(DRE)remain subjects of ongoing research.Consequently,MRgFUS is under investigation to ascertain its effectiveness and safety profile for treating DRE.This review aims to summarize the current progress in the application of MRgFUS for DRE therapy.

关 键 词：药物难治性癫痫 磁共振引导聚焦超声治疗 低强度聚焦超声 高强度聚焦超声 

分 类 号：R74[医药卫生—神经病学与精神病学]