Lcn2 secreted by macrophages through NLRP3 signaling pathway induced severe pneumonia  

作　　者：Mingya Liu Feifei Qi Jue Wang Fengdi Li Qi Lv Ran Deng Xujian Liang Shasha Zhou Pin Yu Yanfeng Xu Yaqing Zhang Yiwei Yan Ming Liu Shuyue Li Guocui Mou Linlin Bao 

机构地区：[1]Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases,NHC Key Laboratory of Comparative Medicine,Institute of Laboratory Animal Science,CAMS&PUMC,Beijing 100021,China [2]National Center of Technology Innovation for Animal Model,Beijing 100021,China [3]State Key Laboratory of Respiratory Health and Multimorbidity,Beijing 100005,China

出　　处：《Protein & Cell》2025年第2期148-155,共8页蛋白质与细胞(英文版)

基　　金：supported by the National Research and Development Project of China(grant no.2023YFF0724800);the CAMS Initiative for Innovative Medicine of China(grant no.2021-I2M-1-035);the Sector Fund(2060302);Young Elite Scientists Sponsorship Program by CAST(YESS)(grant no:2020QNRC001)。

摘　　要：Dear Editor,The case fatality rate of early SARS-CoV-2 infection is 3%(Ghebreyesus,2020),and the severe case rate is 24.3%(Sun et al.,2020).From the prototypic SARS-CoV-2 strain to the emergence of Alpha,Beta,and Delta variants,which ultimately led to the outbreak of Omicron variants,these strains have undergone a series of evolutionary changes.Starting from BA.1,BA.2,BA.4,and BA.5 lineage to XBB lineage before branching out into the current dominant JN.1 lineage.

关 键 词：NLRP3 branching ALPHA 

分 类 号：R563.1[医药卫生—呼吸系统]