脑灌注CT影像参数对高龄缺血性脑血管病患者预后的评估价值  

Evaluation Value of Cerebral Perfusion CT Imaging Parameters for Prognosis of Elderly Patients with Ischemic Cerebrovascular Disease

作　　者：许禹[1] 耿云平[1] 尤国庆[1] 马新强[2] XU Yu;GENG Yunping;YOU Guoqing;MA Xinqiang(Department of CT Imaging,Nanyang Central Hospital,Nanyang 473000,China;Department of Neurosurgery,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]南阳市中心医院CT影像科,河南南阳473000 [2]南阳市中心医院神经外科,河南南阳473000

出　　处：《临床医学工程》2025年第2期129-132,共4页Clinical Medicine & Engineering

基　　金：河南省医学科技攻关计划联合共建项目(项目编号:LHGJ20191455)。

摘　　要：目的探讨脑灌注CT影像参数对高龄缺血性脑血管病患者预后的评估价值。方法回顾性分析2020年10月至2024年10月我院收治的80例高龄缺血性脑血管病患者的临床资料,所有患者均接受脑灌注CT检查,获取脑血流量(CBF)、脑血容量(CBV)、平均通过时间(MTT)和达峰时间(TTP)等参数,分为预后良好组(mRS评分≤2分)、预后不良组(mRS评分>2分)。比较两组患者的CBF、CBV、MTT、TTP参数,并分析各参数与mRS评分的相关性。绘制受试者工作特性曲线(ROC)分析各参数对缺血性脑血管病患者预后的评估价值。结果两组患者脑灌注CT影像参数比较比较差异有统计学意义(P<0.05);预后良好组CBF、CBV高于预后不良组,MTT、TTP低于预后不良组。Pearson相关性检验分析显示,CBF(r=-0.648)、CBV(r=-0.522)与mRS评分呈负相关性,MTT(r=0.591)、TTP(r=0.439)与mRS评分呈正相关性(P<0.05)。ROC曲线分析结果显示,CBF、CBV、MTT、TTP对缺血性脑血管病患者预后均具有显著的评估价值(AUC>0.7,P<0.05)。结论脑灌注CT影像参数与高龄缺血性脑血管病患者预后密切相关,对其预后评估具有显著价值,可作为临床评估患者预后的有效参考指标。Objective To explore the evaluation value of cerebral perfusion CT imaging parameters for prognosis of elderly patients with ischemic cerebrovascular disease.Methods 80 elderly patients with ischemic cerebrovascular disease admitted to our hospital from October 2020 to October 2024 were retrospectively analyzed.All patients underwent cerebral perfusion CT examination to obtain parameters such as cerebral blood flow(CBF),cerebral blood volume(CBV),mean transit time(MTT),and time to peak(TTP),and divided into the good prognosis group(mRS score≤2)and the poor prognosis group(mRS score>2).The CBF,CBV,MTT,and TTP parameters were compared between the two groups,and the correlation between each parameter and mRS score was analyzed.Receiver Operating Characteristic(ROC)curve was draw to analyze the evaluation value of various parameters for prognosis of patients with ischemic cerebrovascular disease.Results Statistical difference was found in the cerebral perfusion CT imaging parameters between the two groups(P<0.05).The CBF and CBV of the good prognosis group were higher than those of the poor prognosis group,and the MTT and TTP were lower than those of the poor prognosis group(P<0.05).Pearson correlation analysis showed that CBF(r=-0.648)and CBV(r=-0.522)were negatively correlated with mRS scores,while MTT(r=0.591)and TTP(r=0.439)were positively correlated with mRS scores(P<0.05).ROC curve analysis results showed that the CBF,CBV,MTT and TTP had significant evaluation value for prognosis of patients with ischemic cerebrovascular disease(AUC>0.7,P<0.05).Conclusions The parameters of cerebral perfusion CT imaging are closely related to the prognosis of elderly patients with ischemic cerebrovascular disease,and have significant value in the evaluation of prognosis,which can be used as effective reference indicators for clinical evaluation of prognosis.

关 键 词：脑灌注CT影像参数 缺血性脑血管病 预后 脑血流量 

分 类 号：R743.3[医药卫生—神经病学与精神病学]