生长抑素类似物PET/CT显像在神经内分泌肿瘤中的应用现状与进展  

The current status and progress of PET/CT imaging of somatostatin analogs in neuroendocrine tumors

作　　者：刘逸飞 曲蕾 徐帅帅 姚树展 LIU Yifei;QU Lei;XU Shuaishuai;YAO Shuzhan(Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250017,China;Department of Nuclear Medicine,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学(山东省医学科学院),山东济南250017 [2]山东第一医科大学附属省立医院核医学科,山东济南250021

出　　处：《医学影像学杂志》2025年第2期139-142,共4页Journal of Medical Imaging

摘　　要：神经内分泌肿瘤(NENs)起源于神经内分泌细胞,多见于消化系统。生长抑素受体(SSTR)在NEN细胞上普遍过表达,为成像提供了一个独特、特定的分子靶点。奥曲肽是一种合成的生长抑素类似物(SSA),在1983年首次被放射性标记,可以用核医学伽马相机进行SSTR成像。目前,已经将^(111)In-pentetreotide,^(68)Ga-SSA,^(18)F-SSA,^(64)Cu-SSA等放射性标记药物用于NEN成像。Neuroendocrine neoplasms(NENs)arise from the diffuse neuroendocrine cells and most frequently occur in the digestive system.Somatostatin receptors(SSTR)are overexpressed on a wide range of NEN cells,providing a unique and specific molecular target for imaging.Octreotide is a synthetic somatostatin analog(SSA),which was first radiolabeled in 1983,allowing SSTR imaging with a nuclear medicine gamma camera.Currently,several radiolabeled drugs including ^(111)In-pentetreotide,^(68)Ga-SSA,^(18)F-SSA,^(64)Cu-SSA have been used in the imaging of NENs.

关 键 词：NENs 放射性同位素 正电子发射断层技术 体层摄影术 X线计算机 

分 类 号：R739.4[医药卫生—肿瘤] R817.4[医药卫生—临床医学]