消化内镜下黏膜剥离术治疗早期结直肠癌的效果及对血清CA125、CA153、CA199的影响  

Effect of Endoscopic Submucosal Dissection in the Treatment of Early Colorectal Cancer and Its Impact on Serum Levels of CA125,CA153 and CA199

作　　者：杨眉 涂金杰 YANG Mei;TU Jinjie(Xiaogan First People's Hospital,Xiaogan 432000,China;不详)

机构地区：[1]孝感市第一人民医院,湖北孝感432000

出　　处：《中外医学研究》2025年第7期1-4,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：2022年度孝感市自然科学计划项目(XGKJ2022010052)。

摘　　要：目的:探讨消化内镜下黏膜剥离术(endoscopic submucosal dissection,ESD)治疗早期结直肠癌的效果及对血清糖类抗原125(carbohydrate antigen 125,CA125)、糖类抗原153(carbohydrate antigen 153,CA153)、糖类抗原199(carbohydrate antigen 199,CA199)的影响。方法:选取2022年2月—2024年2月孝感市第一人民医院收治的102例早期结直肠癌患者作为研究对象,根据治疗术式不同将患者分为对照组(n=50)与试验组(n=52)。对照组采用消化内镜下黏膜切除术(endoscopic mucosal resection,EMR)治疗,试验组采用ESD治疗。比较两组切除效果,手术指标,血清CA125、CA153、CA199水平及并发症发生情况。结果:试验组整块切除率和组织治愈性切除率分别为96.15%、92.31%,均高于对照组的84.00%、76.00%,差异有统计学意义(P<0.05)。试验组手术时间长于对照组,差异有统计学意义(P<0.05);两组术中出血量比较,差异无统计学意义(P>0.05)。术后1个月,两组CA125、CA153、CA199水平较术前降低,且试验组低于对照组,差异有统计学意义(P<0.05)。试验组并发症发生率为9.61%,与对照组的8.00%比较,差异无统计学意义(P>0.05)。结论:ESD治疗早期结直肠癌能提高癌灶切除效果,未增加术中出血量,降低血清肿瘤标志物水平,且安全性良好,但手术时间较长。Objective:To investigate the effect of endoscopic submucosal dissection(ESD)in the treatment of early colorectal cancer and its impact on serum carbohydrate antigen 125(CA125),carbohydrate antigen 153(CA153)and carbohydrate antigen 199(CA199).Method:A total of 102 patients with early colorectal cancer who admitted to Xiaogan First People's Hospital from February 2022 to February 2024 were selected as the research objects,the patients were divided into the control group(n=50)and the experimental group(n=52)according to different treatment methods.The control group was treated with endoscopic mucosal resection(EMR),and the experimental group was treated with ESD.The resection effect,surgical indicators,serum CA125,CA153,CA199 levels and complications were compared between two groups.Result:The overall resection rate and tissue curative resection rate in the experimental group were 96.15%and 92.31%,respectively,which were higher than 84.00%and 76.00%in the control group,the differences were statistically significant(P<0.05).The surgical time of the experimental group was longer than that of the control group,the difference was statistically significant(P<0.05);there was no significant difference in the amount of intraoperative blood loss between two groups(P>0.05).At 1 month after operation,the levels of CA125,CA153 and CA199 in two groups were lower than those before operation,and those in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of complications in the experimental group was 9.61%,compared with 8.00%in the control group,the difference was not statistically significant(P>0.05).Conclusion:ESD in the treatment of early colorectal cancer can improve the effect of tumor resection,without increasing the amount of intraoperative blood loss,reduce the level of serum tumor markers,and has good safety,but the operation time is longer.

关 键 词：早期结直肠癌 消化内镜下黏膜剥离术 疗效 糖类抗原125 糖类抗原153 糖类抗原199 

分 类 号：R735.34[医药卫生—肿瘤]