布拉式酵母菌散联合四联疗法对Hp阳性慢性萎缩性胃炎患者Hp清除率、胃肠激素水平及免疫功能的影响  

Effect of Saccharomyces Boulardii Sachets Combined with Quadruple Therapy on Hp Clearance Rate,Gastrointestinal Hormone Level and Immune Function of Patients with Hp-positive Chronic Atrophic Gastritis

作　　者：涂金杰 杨眉 TU Jinjie;YANG Mei(Xiaogan First People's Hospital,Xiaogan 432000,China;不详)

机构地区：[1]孝感市第一人民医院,湖北孝感432000

出　　处：《中外医学研究》2025年第7期23-26,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：2022年度孝感市自然科学计划项目(XGKJ2022010051)。

摘　　要：目的:探讨布拉式酵母菌散联合四联疗法对幽门螺杆菌(Hp)阳性慢性萎缩性胃炎患者Hp清除率、胃肠激素水平及免疫功能的影响。方法:选取2022年7月—2023年6月孝感市第一人民医院收治的300例Hp阳性慢性萎缩性胃炎患者作为研究对象,按照随机数表法将患者分为对照组(n=149,四联疗法)、联合组(n=151,布拉式酵母菌散联合四联疗法)。比较两组Hp清除率、胃肠激素水平、免疫功能变化,并记录不良反应发生情况。结果:联合组Hp清除率为94.04%,高于对照组的87.25%,差异有统计学意义(P<0.05);治疗后,两组胃蛋白酶原Ⅰ(PGⅠ)、胃泌素17(G-17)、胃动素(MTL)、CD8^(+)水平较治疗前降低,且联合组较对照组更低,两组CD3^(+)、CD4^(+)水平较治疗前升高,且联合组较对照组更高,差异有统计学意义(P<0.05);联合组不良反应发生率为3.97%,低于对照组的10.74%,差异有统计学意义(P<0.05)。结论:布拉式酵母菌散联合四联疗法治疗Hp阳性慢性萎缩性胃炎能提高Hp清除率,有效调节胃肠激素水平,提高机体免疫功能,降低不良反应发生率。Objective:To explore the effect of Saccharomyces Boulardii Sachets combined with quadruple therapy on Helicobacter pylori(Hp)clearance rate,gastrointestinal hormone level and immune function of patients with Hp-positive chronic atrophic gastritis.Method:A total of 300 patients with Hp-positive chronic atrophic gastritis who admitted to Xiaogan First People's Hospital from July 2022 to June 2023 were selected as the research objects,the patients were divided into the control group(n=149,quadruple therapy)and the combined group(n=151,Saccharomyces Boulardii Sachets combined with quadruple therapy)according to the random number table method.The Hp clearance rate,gastrointestinal hormone level and immune function changes were compared between two groups,and the incidence of adverse reactions was recorded.Result:The Hp clearance rate of the combined group was 94.04%,which was higher than 87.25%of the control group,and the difference was statistically significant(P<0.05);after treatment,the levels of pepsinogenⅠ(PGⅠ),gastrin 17(G-17),motilin(MTL)and CD8^(+)in two groups were lower than those before treatment,and those in the combined group were lower than the control group,the levels of CD3^(+)and CD4^(+)in two groups were higher than those before treatment,and those in the combined group were higher than those in the control group,the differences were statistically significant(P<0.05);the incidence of adverse reactions in the combination group was 3.97%,which was lower than 10.74%in the control group,the difference was statistically significant(P<0.05).Conclusion:Saccharomyces Boulardii Sachets combined with quadruple therapy in the treatment of Hp-positive chronic atrophic gastritis can improve Hp clearance rate,effectively regulate gastrointestinal hormone level,enhance immune function,and reduce the incidence of adverse reactions.

关 键 词：幽门螺杆菌感染 慢性萎缩性胃炎 布拉式酵母菌散 四联疗法 Hp清除率 胃肠激素 免疫功能 

分 类 号：R57[医药卫生—消化系统]