椎间盘退变动物模型研究进展  

Research Progress on Animal Models of Intervertebral Disc Degeneration

作　　者：李青融 张亚峰 LI Qingrong;ZHANG Yafeng(Graduate School of Nanjing University of Chinese Medicine,Nanjing 210023,China;不详)

机构地区：[1]南京中医药大学研究生院,江苏南京210023 [2]南京中医药大学附属无锡医院

出　　处：《中外医学研究》2025年第7期164-168,共5页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：江苏省中医临床创新中心(重点项目)(2021040501);吴阶平医学基金会临床科研项目(320.6750.2023-03-49)。

摘　　要：椎间盘退变(intervertebral disc degeneration,IDD)是目前公认的工作年龄人群腰痛、致残的重要原因,同时也是一个全球性的健康问题。目前IDD机制仍未明确,因此需要使用动物模型去研究成因、发展过程及治疗方法等。IDD动物模型多种多样,各有利弊,可分为诱发类、基因类、自发类等。文章论述了IDD动物模型的造模方法,为椎间盘退行性疾病的研究提供参考。Intervertebral disc degeneration(IDD)is now recognized as an important cause of low back pain and disability in people of working age,it is a global health problem.At present,the IDD mechanism is not clear,so animal models need to be used to study causes,development processes and treatment methods.IDD animal models are diverse,each with advantages and disadvantages,which can be divided into induction,genes,spontaneous categories,etc.The article discusses the method of making the IDD animal model,which provides a reference for the study of intervertebral disk degenerative diseases.

关 键 词：椎间盘退变 椎间盘退行性疾病 动物模型 造模方法 

分 类 号：R59[医药卫生—内科学]