回生口服液对中晚期非小细胞肺癌气虚血瘀证患者凝血功能和免疫功能的影响  

Effect of Huisheng oral liquid on coagulation function and immune function in patients with middle-advanced non-small cell lung cancer of Qi-deficiency and blood-stasis syndrome

作　　者：谢炉峰 缪继东[1] 蒋朝阳 李家伟[1] 冯江[3] XIE Lufeng;MIAO Jidong;JIANG Chaoyang;LI Jiawei;FENG Jiang(Department of Oncology,Zigong Fourth People's Hospital,Zigong,Sichuan 643000;Department of Radiation Therapy,the General Hospital of Western Theater Command PLA,Chengdu,Sichuan 610083;Department of Obstetrics and Gynecology,Zigong Fourth People's Hospital,Zigong,Sichuan 643000)

机构地区：[1]四川省自贡市第四人民医院肿瘤科,四川自贡643000 [2]中国人民解放军西部战区总医院放射治疗科,四川成都610083 [3]四川省自贡市第四人民医院妇产科,四川自贡643000

出　　处：《河北中医》2025年第3期375-381,共7页Hebei Journal of Traditional Chinese Medicine

基　　金：四川省卫生健康委员会2021年医学科技项目(编号:21PJ068)。

摘　　要：目的观察回生口服液对中晚期非小细胞肺癌(NSCLC)气虚血瘀证患者凝血功能和免疫功能的影响。方法选择2020年3月至2023年3月四川省自贡市第四人民医院肿瘤科86例中晚期NSCLC气虚血瘀证患者为研究对象,按照随机数字表法分为治疗组和对照组,每组43例。2组患者均根据病情选择适宜的化疗方案和阿司匹林肠溶片治疗,治疗组在以上基础上加服回生口服液。比较2组患者T淋巴细胞亚群CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)和自然杀伤(NK)细胞百分比,凝血相关指标凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)水平和中医证候评分变化,并统计比较近期实体瘤疗效和不良反应。结果治疗后,治疗组CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、NK细胞百分比均较本组治疗前明显改善(P<0.05),且与对照组治疗后比较差异也均有统计学意义(P<0.05)。对照组治疗后除NK细胞较本组治疗前明显升高外(P<0.05),CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)均较本组治疗前无明显变化(P>0.05)。治疗后,2组PLT、FIB和D-D水平均降低(P<0.05),PT、APTT延长(P<0.05),且治疗后2组PLT、PT、APTT、FIB、D-D组间比较差异也均有统计学意义(P<0.05)。治疗后治疗组咳痰无力、气短懒言、形体消瘦、神疲乏力、面色晦暗、刺痛评分均较本组治疗前明显降低(P<0.05),且均低于对照组治疗后(P<0.05);治疗后对照组咳痰无力、气短懒言、神疲乏力、面色晦暗、刺痛评分均较本组治疗前明显降低(P<0.05)。治疗结束后1个月,治疗组疾病控制率为76.74%(33/43),对照组为55.81%(24/43),治疗组疾病控制率高于对照组(P<0.05)。治疗组胃肠道反应、白细胞减少、肝损害和肾损害发生率均显著低于对照组(P<0.05)。结论回生口服液能改善中晚期NSCLC气虚血瘀证患者凝血功能和免疫功能。Objective To observe the effects of Huisheng oral liquid on coagulation function and immune function in patients with middle-advanced non-small cell lung cancer(NSCLC)of Qi-deficiency and blood-stasis syndrome.Methods Eighty-six patients with middle-advanced NSCLC of Qi-deficiency and blood-stasis syndrome admitted to the Oncology Department of Zigong Fourth People's Hospital from March 2020 to March 2023 were assigned into treatment group(n=43)and control group(n=43)according to a random number table.All patients received appropriate chemotherapy regimen and aspirin enteric-coated tablets,and those in the treatment group additionally received Huisheng oral liquid.The percentage of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)lymphocyte subsets and natural killer(NK)cells,the changes in prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D)levels and traditional Chinese medicine(TCM)syndrome scores were observed,and the recent efficacy and adverse reactions of solid tumors were statistically compared.Results After treatment,the percentages of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and NK cells in the treatment group were significantly improved compared with those before treatment(P<0.05),and with a statistically significant difference between the treatment group and the control group(P<0.05);simultaneously,the percentag of NK cells in the control group was significantly improved than that before treatment(P<0.05),but the percentages of CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)in the control group were comparable to before treatment(P>0.05).The levels of PLT,FIB and D-D in the both groups were significantly decreased than those before treatment(P<0.05),while the PT and APTT were significantly prolonged(P<0.05),and the indexes were more pronounced in the trearment group relative to the control group(P<0.05).The score of sputum weakness,shortness of breath and lazy speech,body wasting,fatigue,dull complexion and stinging in the treatment group were significantly decreased than those b

关 键 词：癌 非小细胞肺 回生口服液 气虚血瘀 血液凝固 免疫 细胞 

分 类 号：R734.205.31[医药卫生—肿瘤]