脂质体药物递送系统在头颈肿瘤治疗中的基础研究进展  

Research progress of liposome drug delivery system in the treatment of head and neck cancer

作　　者：刘博[1] 凃雅琴 吴楠 肖红俊 LIU Bo;TU Yaqin;WU Nan;XIAO Hongjun(Department of Otorhinolaryngology,Union Hospital of Tongji Medical College of Huazhong University of Science and Technology,Wuhan,430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院耳鼻咽喉科,武汉430022

出　　处：《临床耳鼻咽喉头颈外科杂志》2025年第1期91-96,共6页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金项目(No:82071057)。

摘　　要：头颈肿瘤是危害人类健康的重大疾病之一,靶向化疗是针对头颈肿瘤的一项重要治疗手段。但是,许多抗癌药物难以在肿瘤中达到有效浓度,并会对正常组织造成损害。因此,如何高效递送抗肿瘤药物、提升其治疗效果并降低其对全身和局部的不良反应,是靶向药物研究中亟需解决的问题。脂质体因其独特的特性,包括两亲性,生物相容性,生物降解性,低毒性等,而受到了广泛研究。本文概述了近年来脂质体药物递送系统在头颈肿瘤不同治疗方式中的应用现状及前景,以期为头颈肿瘤的治疗提供更多可选方案。Head and neck tumors are one of the major diseases that threaten human health.Targeted chemotherapy is an important treatment for head and neck tumors.However,many anti-cancer drugs are difficult to reach effective concentrations in tumors and can cause damage to normal tissues.Therefore,the efficient delivery of anti-tumor drugs,improvement of their therapeutic effects,and reduction of their adverse effects on the whole body and locally are urgent issues in targeted drug research.Liposomes have been widely studied due to their unique characteristics,including amphiphilicity,biocompatibility,biodegradability,and low toxicity.This article outlines the current applications and prospects of liposome drug delivery systems in different treatment modalities for head and neck tumors in recent years,aiming to provide more options for the treatment of head and neck tumors.

关 键 词：脂质体 头颈肿瘤 药物递送系统 肿瘤治疗 

分 类 号：R739.91[医药卫生—肿瘤]