牙槽骨缺损修复的组织工程新进展  

Recent advances in tissue engineering for alveolar bone defect repair

作　　者：范子露(综述) 罗栩伟(综述)[2] 谢永林(审校)[1] FAN Zilu;LUO Xuwei;XIE Yonglin(Department of Stomatology,Beijing Anzhen Nanchong Hospital of Capital Medical University,The Second Clinical Medical College of North Sichuan Medical University,Nanchong 637000,Sichuan,China;Institute of Tissue Engineering and Stem Cell,Beijing Anzhen Nanchong Hospital of Capital Medical University,The Second Clinical Medical College of Capital Medical University,North Sichuan Medical University,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院第二临床医学院·首都医科大学附属北京安贞医院南充医院口腔科,四川南充637000 [2]川北医学院第二临床医学院·首都医科大学附属北京安贞医院南充医院组织工程与干细胞研究所,四川南充637000

出　　处：《西部医学》2025年第3期463-468,共6页Medical Journal of West China

基　　金：四川省自然科学基金项目面上项目(2022NSFSC0609);南充市市校科技战略合作项目(22SXQT0390,22SXQT0386)。

摘　　要：牙槽骨缺损常由于外伤、牙齿拔除或骨质疾病引起,对于患者咀嚼功能和面部外观都可能带来严重的影响。随着人口老龄化趋势的增加,对于牙槽骨缺损修复的需求日益凸显。传统的修复方法往往面临着术后愈合周期长、效果难以预测等问题。因此,研究者们迫切寻求更创新、高效的修复手段,以提高患者的生活质量。近年来,组织工程学和材料科学的迅速发展为牙槽骨缺损修复提供了全新的研究方向。本综述深入剖析了当前牙槽骨缺损修复领域的前沿研究,聚焦于生物材料的前沿应用,例如人工骨料和生物活性物质,这些创新材料为骨组织再生提供了强有力的支持。同时,干细胞技术的巧妙引入为治疗个性化提供了新思路,通过促进骨组织再生迅速推动修复过程。在技术的最前沿,3D打印技术展示了根据个体需求定制复杂结构的潜能。生长因子的精准运用成为调控骨细胞分化和增殖的关键策略。这些发现不仅反映了当前科技和医学的创新潮流,更为未来治疗牙槽骨缺损提供了引人瞩目的展望,为读者提供了对这一领域深刻理解的机会。Alveolar bone defects often result from trauma,tooth extraction,or bone disorders,potentially causing significant impacts on patients'masticatory function and facial appearance.With the increasing trend of population aging,the demand for repairing alveolar bone defects is becoming more pronounced.Traditional repair methods often face challenges such as extended postoperative healing periods and unpredictable outcomes.Consequently,researchers urgently seek more innovative and efficient repair methods to enhance patients'quality of life.In recent years,the rapid development of tissue engineering and materials science has provided a new research direction for the repair of alveolar bone defects.This review thoroughly analyzes the current forefront research in the field of alveolar bone defect repair,focusing on the cutting-edge application of biomaterials,such as artificial bone grafts and bioactive substances.These innovative materials offer robust support for bone tissue regeneration.Simultaneously,the clever introduction of stem cell technology provides new avenues for personalized treatments,rapidly advancing the repair process by promoting bone tissue regeneration.At the forefront of technology,3D printing demonstrates the potential to customize complex structures based on individual needs.The precise application of growth factors emerges as a crucial strategy in regulating bone cell differentiation and proliferation.These findings not only reflect the current innovative trends in technology and medicine but also present promising prospects for the future treatment of alveolar bone defects,providing readers with an opportunity for a profound understanding of this field.

关 键 词：牙槽骨缺损 组织工程 3D打印 干细胞技术 个体化治疗 

分 类 号：R782[医药卫生—口腔医学]