基于食管鳞癌双硫死亡相关lncRNA预后模型的构建  

Construction of a prognostic model based on disulfide death-related lncRNA in esophageal squamous cell carcinoma

作　　者：刘佳[1,2] 赵蒙蒙 杨凯歌 胡建明[1,2] LIU Jia;ZHAO Mengmeng;YANG Kaige;HU Jianming(Shihezi University,Shihezi 832003;Pathology Department,the First Affiliated Hospital of Shihezi University,Shihezi 832008,China)

机构地区：[1]石河子大学,新疆石河子832003 [2]石河子大学第一附属医院病理科,新疆石河子832008

出　　处：《临床医学研究与实践》2025年第7期13-16,共4页Clinical Research and Practice

基　　金：2023年度新疆生产建设兵团财政科技计划项目(No.2023AB058);新疆生产建设兵团科技计划项目(No.2022DZ003)。

摘　　要：目的筛选与食管鳞癌双硫死亡相关的lncRNA,构建预后模型,为临床治疗提供方向。方法从癌症基因组图谱(TCGA)数据库中下载RNA-seq数据以及相应的临床和预后数据,进行单因素和多因素Cox回归分析,获得与双硫死亡相关的lncRNA,构建预后模型;采用Kaplan-Meier法分析高危组和低危组的总生存率(OS)。结果构建了由9个与双硫死亡相关的lncRNA(AC092484.1、AC083799.1、LINC01770、AC138207.5、AC012467.2、AC104041.1、AC118755.1、NALT1、IPO5P1)组成的预后模型。Kaplan-Meier生存分析结果显示,高危组的OS低于低危组(P<0.05),预后模型可以独立预测食管鳞癌患者的预后。结论9个双硫死亡相关lncRNA的风险模型是食管鳞癌的独立预后因素。本研究为食管鳞癌的研究提供了一个新的视角,有助于促进临床双硫死亡相关治疗与管理。Objective To screen lncRNA related to disulfide death in esophageal squamous cell carcinoma,construct a prognostic model,and provide direction for clinical treatment.Methods RNA-seq data and corresponding clinical and prognostic data were downloaded from the Cancer Genome Atlas(TCGA)database,and univariate and multivariate Cox regression analysis was performed to obtain lncRNA related to disulfide death and construct a prognostic model;Kaplan-Meier method was used to analyze the overall survival(OS)of the high-risk group and the low-risk group.Results A prognostic model consisting of 9 lncRNAs(AC092484.1,AC083799.1,LINC01770,AC138207.5,AC012467.2,AC104041.1,AC118755.1,NALT1,IPO5P1)related to disulfide death was constructed.Kaplan-Meier survival result analysis showed that the OS of the high-risk group was lower than that of the low-risk group(P<0.05),and the prognostic model could independently predict the prognosis of patients with esophageal squamous cell carcinoma.Conclusion The risk model of 9 disulfide death-related lncRNAs is an independent prognostic factor for esophageal squamous cell carcinoma.This study provides a new perspective for the study of esophageal squamous cell carcinoma and helps to promote clinical disulfide death-related treatment and management.

关 键 词：食管鳞癌 双硫死亡 长链非编码RNA 预后模型 

分 类 号：R735.1[医药卫生—肿瘤]