Th9/Treg细胞失衡对宫颈癌合并高危型HPV感染患者临床预后的影响  

The Impact of Th9/Treg Cell Imbalance on the Clinical Prognosis of Cervical Cancer Patients with High-risk HPV Infection

作　　者：石光辉 刘莉[1] 任杰 SHI Guanghui;LIU Li;REN Jie(Zhoukou Central Hospital,Zhoukou,466000)

机构地区：[1]河南省周口市中心医院,466000

出　　处：《实用癌症杂志》2025年第3期394-397,405,共5页The Practical Journal of Cancer

摘　　要：目的 探讨辅助性T细胞9(Th9)/调节性T细胞(Treg)失衡对宫颈癌合并宫颈高危型人乳头瘤病毒(HR-HPV)感染患者临床预后的影响。方法 回顾性收集完成3个化疗周期及1年随访的92例宫颈癌合并宫颈HR-HPV感染患者的临床资料,收集患者基线资料及入院时Th9、Treg水平,计算Th9/Treg比值,分析Th9/Treg细胞失衡对宫颈癌合并宫颈HR-HPV感染患者临床预后的影响。结果 随访期间,92例宫颈癌合并宫颈HR-HPV感染患者中病死20例,生存72例,病死率为21.74%;病死组临床分期Ⅲ期、肿瘤直径>5 cm及血清鳞状上皮细胞癌抗原水平、Th9、Treg水平均高于生存组,Th9/Treg值低于生存组,差异有统计学意义(P<0.05);经Cox回归分析显示,临床分期Ⅲ期、肿瘤直径>5 cm、血清鳞状上皮细胞癌抗原水平高、Th9水平高、Treg水平高、Th9/Treg比值低是宫颈癌合并宫颈HR-HPV感染患者临床预后不良的危险因素(P<0.05)。结论 Th9/Treg细胞失衡是宫颈癌合并宫颈HR-HPV感染患者临床预后不良的危险因素。Objective To investigate the impact of helper T cell 9(Th9)/regulatory T cell(Treg)imbalance on the clinical prognosis of cervical cancer patients with high-risk human papilloma virus(HR-HPV)infection.Methods A retrospective collection of clinical data was conducted on 92 patients with cervical cancer complicated with cervical HR-HPV infection who completed three chemotherapy cycles and were followed up for one year in the hospital.The baseline data of patients and the levels of Th9 and Treg at admission were collected,and the ratio of Th9/Treg was calculated.The effect of Th9/Treg cell imbalance on the clinical prognosis of patients with cervical cancer complicated with cervical HR-HPV infection was analyzed.Results During the follow-up period,among 92 patients with cervical cancer complicated by cervical HR-HPV infection,20 died and 72 survived,with a mortality rate of 21.74%.The clinical stageⅢ,tumor diameter>5cm,serum squamous cell carcinoma antigen levels,Th9 and Treg levels in the mortality group were higher than those in the survival group,and Th9/Treg values were lower than those in the survival group,with a statistical significant difference(P<0.05).Cox regression analysis showed that clinical stageⅢ,tumor diameter>5cm,high serum squamous cell carcinoma antigen levels,high Th9 levels,high Treg levels,and low Th9/Treg ratios were risk factors for poor clinical prognosis in patients with cervical cancer complicated with cervical HR-HPV infection(P<0.05).Conclusion Th9/Treg cell imbalance is a risk factor for poor clinical prognosis in patients with cervical cancer complicated with cervical HR-HPV infection.

关 键 词：宫颈癌 人乳头瘤病毒 辅助性T细胞9 调节性T细胞 预后 

分 类 号：R737.33[医药卫生—肿瘤]