三阴性乳腺癌保乳联合前哨淋巴结活检术治疗后复发转移的影响因素  

Influencing Factors of Breast Conserving Combined with Sentinel Lymph Node Biopsy in the Treatment of Recurrence and Metastasis of Triple-negative Breast Cancer

作　　者：肖溪 郝凯峰 仲广生 闫鹏 XIAO Xi;HAO Kaifeng;ZHONG Guangsheng(Pingmei Shenma medical General Hospital,Pingdingshan,467000)

机构地区：[1]平煤神马医疗集团总医院,467000

出　　处：《实用癌症杂志》2025年第3期440-443,451,共5页The Practical Journal of Cancer

摘　　要：目的 探讨三阴性乳腺癌(TNBC)保乳联合前哨淋巴结活检术治疗后复发转移的影响因素。方法 回顾性分析,收集2018年1月至2020年12月医院接收的100例三阴性乳腺癌患者资料,所有患者均由同组医生实施保乳联合前哨淋巴结活检术。术后随访3年,根据影像学检查或病理检查结果,将随访期间复发转移的患者纳入复发转移组,其余患者纳入未复发转移组,整理并记录患者的人口学资料、病历资料等,重点分析复发转移的影响因素。结果 所有患者均完成3年随访,其中有23例患者复发转移,复发转移率为23.0%。研究发现,TNBC患者保乳联合前哨淋巴结活检术后复发转移可能与患者年龄、肿瘤直径、肿瘤分期、是否伴脉管癌栓有关(P<0.05)。将可能的因素纳入,经Logistic回归分析显示,年龄≥50岁、肿瘤直径≥2 cm、肿瘤分期为Ⅲ期、伴有脉管癌栓是TNBC患者保乳联合前哨淋巴结活检术后复发转移的危险因素(OR>1,P<0.05)。结论 TNBC患者经保乳联合前哨淋巴结活检术治疗后仍有较高的复发转移风险,可能与年龄、肿瘤直径、肿瘤分期、伴有脉管栓癌有关,对于年龄≥50岁、肿瘤直径≥2 cm、肿瘤分期为Ⅲ期、伴有脉管栓癌的患者应加以重视。Objective To analyze the influencing factors of breast conserving combined with sentinel lymph node biopsy in the treatment of recurrence and metastasis of triple-negative breast cancer(TNBC).Methods Retrospective analysis was conducted to collect the data of 100 patients with triple-negative breast cancer.All patients were performed breast conserving combined sentinel lymph node biopsy by the same group of doctors.Follow up for 3 years after surgery,based on imaging or pathological examination results,patients with recurrence and metastasis during the follow-up period were included in the recurrence and metastasis group,and other patients were included in the non recurrence and metastasis group.Patient demographic data,medical records,etc were organized and recorded.The influence factors of recurrence and metastasis were analyzed.Results All patients completed follow-up.23 patients were found to have recurrence and metastasis,with a recurrence and metastasis rate of 23.0%.Study revealed that recurrence and metastasis in TNBC patients after breast conserving combined with sentinel lymph node biopsy may be related to patient age,tumor diameter,tumor stage,and presence of vascular cancer thrombus(P<0.05).Including possible factors,Logistic regression analysis showed that age≥50 years,tumor diameter≥2 cm,tumor stageⅢ,and presence of vascular cancer thrombus were risk factors for recurrence and metastasis in TNBC patients after breast conserving combined with sentinel lymph node biopsy(OR>1,P<0.05).Conclusion TNBC patients who undergo breast conserving combined with sentinel lymph node biopsy still have a high risk of recurrence and metastasis,which may be related to age,tumor diameter,tumor stage,and presence of thrombotic carcinoma.Patients aged≥50 years,tumor diameter≥2 cm,tumor stageⅢ,and with vascular thrombotic carcinoma should be taken seriously.

关 键 词：保乳 前哨淋巴结活检 三阴性乳腺癌 复发转移 影响因素 

分 类 号：R737.9[医药卫生—肿瘤]