小细胞肺癌患者化疗前后癌胚抗原与鳞状上皮细胞癌抗原比值的变化及临床意义  

Changes and Clinical Significance of the Ratio of Carcinoembryonic Antigen to Squamous Cell Carcinoma Antigen in Patients with Small Cell Lung Cancer Before and After Chemotherapy

作　　者：夏芳 何鑫 XIA Fang;HE Xin(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)

机构地区：[1]郑州大学第五附属医院,450000

出　　处：《实用癌症杂志》2025年第3期484-488,共5页The Practical Journal of Cancer

摘　　要：目的 研究癌胚抗原(CEA)与鳞状上皮细胞癌抗原(SCC)的比值在小细胞肺癌患者化疗前后的变化及临床意义。方法 前瞻性选取60例小细胞肺癌患者作为研究对象。所有患者均接受6个周期的化疗。测定并计算所有患者化疗前、化疗3个周期、化疗结束时的CEA/SCC。评估化疗疗效,重点分析CEA/SCC比值在小细胞肺癌患者化疗前后的变化及临床意义。结果 相较于化疗前,化疗3个周期、化疗结束时小细胞肺癌患者的CEA/SCC比值降低,相较于化疗3个周期,化疗结束时的CEA/SCC比值降低,组内整体比较差异有统计学意义(P<0.05)。不同肿瘤分期、肿瘤体积的患者CEA/SCC比值差异有统计学意义(P<0.05)。60例患者经化疗,有效41例,占68.33%。化疗有效组与化疗无效组在化疗后,CEA/SCC比值均降低,且化疗有效组化疗前的CEA/SCC比值显著低于无效组(P>0.05)。限制性立方样条分析,结果显示,CEA/SCC比值与小细胞肺癌患者化疗无效发生的关联强度呈线性剂量反应关系(P<0.05),当CEA/SCC比值阈值取0.74时,小细胞肺癌患者化疗无效发生风险随CEA/SCC比值升高而增加。结论 小细胞肺癌化疗患者化疗前CEA/SCC比值水平较高,随着化疗的开展,CEA/SCC比值有一定降低,但化疗前CEA/SCC比值的异常升高可能会影响化疗整体效果,增加无效风险。Objective To investigate the changes and clinical significance of the ratio of carcinoembryonic antigen(CEA)to squamous cell carcinoma antigen(SCC)in patients with small cell lung cancer before and after chemotherapy.Methods A prospective study was conducted on 60 patients with small cell lung cancer.All patients received 6 cycles of chemotherapy.The CEA/SCC ratio of all patients before chemotherapy,3 cycles of chemotherapy and the end of chemotherapy was measured and calculated.The efficacy of chemotherapy,demographic data and medical records were recorded.The changes and clinical significance of CEA/SCC ratio before and after chemotherapy in patients with small cell lung cancer chemotherapy were analyzed.Results Compared with before chemotherapy,the CEA/SCC ratio of small cell lung cancer patients decreased after 3 cycles of chemotherapy and at the end of chemotherapy.Compared with 3 cycles of chemotherapy,the CEA/SCC ratio decreased at the end of chemotherapy,and the overall difference within the group was statistically significant(P<0.05).There was a statistical significant difference in the CEA/SCC ratio among patients with different tumor stages and tumor volumes(P<0.05).Among the 60 patients who underwent chemotherapy,41 were effective,accounting for 68.33%.After chemotherapy,the CEA/SCC ratio decreased in both the chemotherapy effective group and the chemotherapy ineffective group,and the CEA/SCC ratio before chemotherapy in the chemotherapy effective group was significantly lower than that in the chemotherapy ineffective group(P>0.05).Through restricted cubic spline analysis,the results showed a linear dose-response relationship between the level of CEA/SCC ratio and the occurrence of chemotherapy ineffectiveness in small cell lung cancer patients(P<0.05).When the CEA/SCC ratio threshold was set to 0.74,the risk of ineffective chemotherapy in small cell lung cancer patients increases with the increase of CEA/SCC ratio.Conclusion The level of CEA/SCC ratio in small cell lung cancer patients before chemoth

关 键 词：小细胞肺癌 化疗 癌胚抗原 鳞状上皮细胞癌抗原 比值 相关性 

分 类 号：R734.2[医药卫生—肿瘤]