Assessment of risk prediction scores for venous thromboembolism in ambulatory cancer patients with solid tumors receiving chemotherapy:A comparative analysis  

作　　者：Hamsaveni Muthukumar Wesley Mannirathil Jose Nikhil Krishna Haridas Anjali Sajikumar Nair Keechilat Pavithran 

机构地区：[1]Department of Allied Health Science,Amrita Institute of Medical Sciences and Research,Amrita Vishwa Vidhyapeetham,Kochi,India [2]Department of Medical Oncology,Amrita Institute of Medical Sciences and Research,Amrita Vishwa Vidhyapeetham,Kochi,India [3]Department of Biostatistics,Amrita Institute of Medical Sciences and Research,Amrita Vishwa Vidhyapeetham,Kochi,India

出　　处：《Malignancy Spectrum》2024年第4期332-338,共7页肿瘤学全景(英文)

摘　　要：Objective:Cancer patients have a 4−7-fold increased risk of thrombotic complications due to cancer as well as chemotherapy-induced hypercoagulable state.This study compared the different risk assessment models(Khorana,PROTECHT,CONKO,and COMPASS-CAT scores)that help predict venous thromboembolism(VTE)in ambulatory cancer patients.Early identification of high-risk patients would benefit from thromboprophylaxis,thereby improving the mortality and morbidity due to thrombotic events.Methods:This is a single-center,prospective,cross-sectional study on ambulatory patients with solid malignancy.The study was conducted over six months,from March 2022 to August 2022.Data on VTE predictors were gathered from 230 ambulatory cancer patients undergoing chemotherapy.Results:Among the 230 patients receiving chemotherapy,20 were diagnosed with VTE,with the majority of this population being either diagnosed with gynecological cancer or lung cancer,constituting 25%of VTEdiagnosed patients.The Khorana score,with a VTE accuracy of 83.04%,was found to be the highest,followed by the CONKO(80.00%),PROTECHT(69.57%),COMPASS-CATⅡ(54.35%),and COMPASS-CATⅠ(38.26%)scores.The cumulative incidence of VTE among high-risk patients showed that the PROTECHT score had the highest cumulative incidence(CI=14.28),and the CONKO score had the lowest(CI=9.40).Conclusion:The Khorana score was the most accurate,followed by the CONKO,PROTECHT,and COMPASS-CATⅡscores,while the COMPASSCATⅠscore was the least accurate.Hence,the Khorana scoring is essential for diagnosing VTE in patients with ambulatory cancer treated with chemotherapy.

关 键 词：venous thromboembolism VTE predictors ambulatory cancer patients receiving chemotherapy risk assessment model 

分 类 号：R73[医药卫生—肿瘤]