梅杰综合征患者的临床特征  

Clinical Features of Patients with Meige Syndrome

作　　者：薛艳玲 刘刚 郭强英 刘现忠 陈素英 XUE Yanling;LIU Gang;GUO Qiangying;LIU Xianzhong;CHEN Suying(Department of Ophthalmology,Henan NO.3 Provincial People’s Hospital,Zhengzhou 450006,China)

机构地区：[1]河南省直第三人民医院眼科,河南郑州450006

出　　处：《河南医学研究》2025年第5期778-783,共6页Henan Medical Research

摘　　要：目的分析Meige综合征(MS)的临床特征。方法对MS患者进行问卷调查评估。问卷调查回顾了人口统计学因素、压力事件、口腔手术史、面部手术史或创伤史、失眠史、精神疾病史、家族史、症状的变化(晨起、平躺、一天之中)、加重及减轻情况、感觉诡计(ST)、症状、确诊时间(从患病至诊断为MS或者眼睑痉挛的时间)、就诊次数、确诊科室、就诊科室和诊断情况。结果在100例患者中,70例(70%)为女性,年龄(57.4±8.0)岁。40%的患者报告在症状出现之前有压力事件。37%的患者报告有口腔手术史,13%的患者报告有面部手术或创伤史。58例患者(58%)被诊断为失眠,12例患者(12%)被诊断为抑郁症,9例患者(9%)被诊断为焦虑症。12%的患者报告有神经或精神疾病家族史。71%的患者晨起症状减轻,73%的患者平躺症状减轻,3%的患者一天之中症状减轻。62%的患者报告有加重因素,43%的患者报告有缓解因素。64%的患者有ST。99%的患者报告有睁眼困难的症状,74%的患者报告有畏光的症状。患者的确诊时间为12.0(7.0,25.5)月,就诊次数为4(2,6)次,就诊较多的科室眼科和神经内科,诊断正确率较高的科室为神经外科和神经内科,最易被误诊为干眼症。结论本研究首次对中国MS患者的就诊情况进行总结,可能有助于提高临床医生对MS的认识,提高诊疗水平。Objective To analyze the clinical features of Meige syndrome(MS).Methods Patients diagnosed with MS were evaluated using questionnaire.The questionnaire reviewed demographic factors,stressful events,history of oral surgery,history of facial surgery or trauma,insomnia,history of mental illness,family history,changes in symptoms(morning,lying flat,throughout the day),aggravating and relieving factors,sensory trick(ST),symptoms,diagnosis time(time from the illness to the diagnosis of MS or blepharospasm),number of visits,confirmed department,medical departments and diagnosis conditions.Results Of the 100 patients enrolled,70(70%)were female,with a age of(57.4±8.0)years.Forty percent of patients reported stressful events immediately prior to symptom development.Thirty-seven percent of patients reported a history of oral surgery and 13%reported a history of facial surgery or trauma.Fifty-eight patients(58%)were diagnosed with insomnia,12 patients(12%)were diagnosed with depression,and nine patients(9%)were diagnosed with anxiety disorders.Twelve percent of patients reported a family history of neurological or psychiatric illness.Morning symptoms decreased in 71%of patients,lying symptoms decreased in 73%of patients,symptoms were reduced in 3%of patients throughout the day.Sixty-two percent of patients reported aggravating factors,forty-three percent of patients reported relieving factors.Sensory trick was present in 64%of the patients.Ninety-nine percent of patients reported symptoms of difficulty in opening their eyes,74%of patients reported symptoms of photophobia.The average time of diagnosis of patients was 12.0(7.0,25.5)months,and the number of visits was 4(2,6)times.Ophthalmology and neurology were the departments with the most frequent visits,and neurosurgery and neurology were the departments with the highest diagnostic accuracy,which were most easily misdiagnosed as dry eye.Conclusion This study is the first to summarize the visits of Chinese patients with MS,which may help to improve clinicians’awareness

关 键 词：MEIGE综合征 临床特征 感觉诡计 

分 类 号：R77[医药卫生—眼科]