PSA联合血栓弹力图对前列腺癌骨转移诊断价值的研究  

Study on the value of PSA combined with thromboelogram for diagnosis of bone metastasis in prostate cancer

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作  者:黄再千 叶昶 HUANG Zaiqian;YE Chang(Wuhan University of Science and Technology,Xiaogan Central Hospital,Xiaogan 432000,China)

机构地区:[1]武汉科技大学附属孝感医院泌尿外科武汉科技大学医学部医学院,孝感432000 [2]武汉科技大学附属孝感医院泌尿外科

出  处:《现代泌尿生殖肿瘤杂志》2025年第1期9-13,共5页Journal of Contemporary Urologic and Reproductive Oncology

摘  要:目的探讨PSA联合血栓弹力图在前列腺癌骨转移中的诊断价值。方法收集湖北省孝感市中心医院2018年1月至2021年12月126例经病理学检查病理确诊为前列腺癌的患者资料,使用SPECT行骨扫描,对于骨扫描难以判断者,使用磁共振成像协助判断。其中36例为骨转移组,90例为无骨转移组,分析包括患者PSA水平、骨转移情况、年龄等资料。比较两组患者的一般资料及血栓弹力图的凝血反应时间(R值)、纤维蛋白功能(K值)、TEG两条曲线最大曲线弧度切线形成的角度(Angle值)、最大振幅(MA值)、纤溶指数(LY30)、预测纤溶指数(EPL),通过受试者工作特征曲线分析PSA、血栓弹力图的K值、Angle值、MA值及其联合指标的诊断价值。结果两组患者的TEG中K值、Angle值、MA值差异有统计学意义(P<0.05),其中指标K值联合PSA的曲线下面积为0.799,大于单一指标PSA的诊断价值(P<0.05),展现出较好的诊断能力和更高的特异性。结论血栓弹力图中K值联合PSA对于前列腺癌骨转移具有一定的诊断价值。Objective To investigate the diagnostic value of PSA combined with thromboelogram in bone metastasis of prostate cancer.Methods The data of 126 patients diagnosed with prostate cancer by pathological examination in Xiaogan Central Hospital of Hubei Province from January 2018 to December 2021 were collected.Bone scanning was performed using SPECT,and magnetic resonance imaging was used to assist in judgment for those who were difficult to judge by bone scanning.Thirty-six patients(28.6%)were in bone metastasis group and 90 patients(71.4%)were in non-bone metastasis group.Their prostate-specific antigen(PSA)level,bone metastasis status and age were analyzed.The general data and the thrombogram time(reaction time,R value),fibrin function(coagulation time,K value),angle formed by maximum curve radian tangent of TEG(angle Aipha,Angle value),maximum amplitude(MA value),fibrinolytic index(Estimated Percentage of Lysis 30,LY 30),the predicted fibrinolytic index(Elasticity Platelet Analyzer,EPL)were compared between the two groups.PSA,K value,Angle value,MA value and combined indexes were analyzed by the receiver operating characteristic curve.Results There were significant statistical differences in K,Angle and MA values in the TEG(P<0.05).The AUC of index K value combined with PSA was 0.799,which was greater than the diagnostic value of single index PSA(P<0.05),showing better diagnostic ability and higher specificity.Conclusions K value in thromboelogram combined with PSA value has high diagnostic value for bone metastasis of prostate cancer.

关 键 词:血栓弹力图 前列腺癌 骨转移 诊断价值 前列腺特异抗原 

分 类 号:R73[医药卫生—肿瘤]

 

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