Imaging of pain using positron emission tomography  

作　　者：Yu‐Peng Zhou Lauren L.Zhang Yang Sun Pedro Brugarolas 

机构地区：[1]Department of Radiology,Massachusetts General Hospital and Harvard Medical School,Boston,Massachusetts,USA [2]Zhongshan Institute for Drug Discovery,Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Zhongshan,Guangdong,52800,China

出　　处：《iRADIOLOGY》2024年第3期339-361,共23页融合影像学(英文)

基　　金：National Institute of Biomedical Imaging and Bioengineering,Grant/Award Number:K99EB033407;National Institute of Neurological Disorders and Stroke,Grant/Award Number:R21NS120139。

摘　　要：Positron emission tomography(PET)is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes.As such,PET can provide important pathophysiological information associated with pain of different etiologies.Consequently,the information obtained using PET often combined with magnetic resonance imaging or computed tomography can provide useful information for diagnosing and monitoring changes associated with pain.This review covers the most important PET tracers that have been used to image pain including tracers for fundamental biological processes such as glucose metabolism and cerebral blood flow,to receptor‐specific tracers such as ion channels and neurotransmitters.For each tracer,we describe the structure and radiochemical synthesis of the tracer followed by a brief summary of the available preclinical and clinical studies.By providing a summary of the PET tracers that have been employed for PET imaging of pain,this review aims to serve as a reference for preclinical,translational,and clinical investigators interested in molecular imaging of pain.Finally,the review ends with an outlook of the needs and opportunities in this area.

关 键 词：MOLECULAR IMAGING PAIN PET TRACER POSITRON emission TOMOGRAPHY 

分 类 号：R73[医药卫生—肿瘤]