White Matter Hyperintensities:Cerebral Small-Vessel Diseases and White Matter Microstructural Impairments  

作　　者：Hui Huang Wei Song Pengyu Wang Ye Zhu Lei Zheng Chenzhen Shen Hui Xu Jianfeng Qiu 

机构地区：[1]Medical Imaging Department,People's Hospital of Yangzhong City,Yangzhong,China [2]Department of Radiology,Shandong First Medical University,Taian,China [3]Department of Radiology,Rushan Hospital of Traditional Chinese Medicine,Rushan,China

出　　处：《iRADIOLOGY》2025年第1期5-25,共21页融合影像学(英文)

基　　金：supported by a grant from the Natural Science Foundation of Shandong Provincial,China(No.ZR2020MH328).

摘　　要：White matter hyperintensities(WMH)are very widespread in older adults and are imaging features of both cerebral small-vessel disease and white matter microstructural impairments.Recent studies have demonstrated a close association between WMH and some common diseases in older adults,including Alzheimer's disease and hypertension.Thus,studies of WMH are important for avoiding the occurrence of these diseases and improving the health status of older adults.This review summarizes the literature relating to WMH in terms of epidemiology,clinical presentation,pathogenesis,imaging features,and therapy.It also analyzes the limitations of present studies and provides perspectives on future directions.

关 键 词：Alzheimer's disease cerebral small-vessel disease HYPERTENSION pathogenesis and imaging white matter hyperintensities 

分 类 号：R74[医药卫生—神经病学与精神病学]