国内外婴儿胆汁淤积性肝病研究的可视化对比分析  

A visual comparative analysis of domestic and international research on infantile cholestatic hepatopathy

作　　者：周丽[1] 李腾飞 徐晓红[1] 连娇燕 王宝林[1] 杨早娟 ZHOU Li;LI Tengfei;XU Xiaohong;LIAN Jiaoyan;WANG Baolin;YANG Zaojuan(Department of Gastroenterology,Gansu Provincial Maternity and Child Health Hospital(Gansu Provincial CentralHospital),Lanzhou 730050,China;School of Nursing,Gansu University of Chinese Medicine,Lanzhou 730000,China;Center for Evidence-Based Medicine,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]甘肃省妇幼保健院(甘肃省中心医院)消化科,甘肃兰州730050 [2]甘肃中医药大学护理学院,甘肃兰州730000 [3]兰州大学基础医学院循证医学中心,甘肃兰州730000

出　　处：《兰州大学学报(医学版)》2025年第1期53-61,共9页Journal of Lanzhou University(Medical Sciences)

基　　金：甘肃省自然科学基金资助项目(21JR11RA178)。

摘　　要：目的深入分析婴儿胆汁淤积性肝病(ICH)领域的研究现状、热点和前沿趋势,以期为该领域未来的发展提供参考。方法采用文献计量学方法,检索中国知网和Web of Science数据库2004-2023年发表的ICH相关文献。利用Excel 2021统计分析文献的年发文量、发表国家、作者。用VOSviewer 1.6.13软件构建国家、作者合作关系图和关键词共现聚类图,用R(4.3.1版)Bibliometrix包(3.13版)绘制年度热点变化趋势图。结果共纳入中文文献666篇,英文文献1812篇,发文量整体呈上升趋势。美国、中国、英国为发文量排名前三的国家。中文文献倾向于ICH的感染因素和药物治疗,英文文献则更关注遗传学分析、综合治疗策略和疾病预后。遗传学研究、个性化营养管理,创新的基因诊断技术或将成为未来研究的趋势。结论美国在ICH研究中处于领先地位。中、英文文献虽有共性,但在侧重点上存在差异。未来研究应重点关注遗传学机制、个性化营养管理和基因诊断技术。Objective To conduct a deep analysis of the current status,hotspots,and frontier trends in the field of infantile cholestatic hepatopathy(ICH)at home and abroad,in order to provide a reference for future development of this field in China.Methods A bibliometric approach was used to search for ICH-related literature published from 2004 to 2023 in the China National Knowledge Infrastructure and Web of Science databases.Analyses were conducted using Excel 2021 to assess annual publication volumes,publication countries and authors.VOSviewer 1.6.13 software was employed to construct maps of national,author collaborations,and keyword co-occurrence clusters,and R(version 4.3.1)Bibliometrix package(version 3.13)used to plot annual trend graphs of research hotspots.Results A total of 666 articles in Chinese literature and 1812 in English literature were included,and the overall publication volume of ICH literature at home and abroad showed an upward trend.The United States,China,and the United Kingdom were the top three countries in terms of publication volume.The Chinese literature tended to focus on the infectious factors and drug treatment of ICH,while the English literature paid more attention to genetic analysis,comprehensive treatment strategies,and disease prognosis.Genetic research,personalized nutritional management,and innovative gene diagnostic technologies might become the frontier trends in future research.Conclusions The United States leads in ICH research.Although there are common grounds between Chinese and English literature,their focus areas differ.Future research should emphasize genetic mechanisms,personalized nutrition management,and gene diagnostic technologies.

关 键 词：婴儿胆汁淤积性肝病 研究热点 前沿趋势 文献计量学 基因诊断 营养管理 

分 类 号：R725.7[医药卫生—儿科]