毓麟珠汤剂联合西药治疗多囊卵巢综合征不孕症的临床效果  

Clinical effect of Yulinzhu decoction combined with western medicine in the treatment of polycystic ovary syndrome infertility

作　　者：王杰 刘灵 李英 李娜 Wang Jie;Liu Ling;Li Ying;Li Na(Department of Pharmacy,Tangshan Maternal and Child Health Hospital,Tangshan Hebei 063000;Department of Pharmacy,Tangshan People's Hospital,Tangshan Hebei 063001;Department of Traditional Chinese Medicine Record,Tangshan Maternal and Child Health Hospital,Tangshan Hebei 063000,P.R.China)

机构地区：[1]唐山市妇幼保健院药剂科,河北唐山063000 [2]唐山市人民医院药剂科,河北唐山063001 [3]唐山市妇幼保健院中医科,河北唐山063000

出　　处：《中国计划生育和妇产科》2025年第2期89-93,共5页Chinese Journal of Family Planning & Gynecotokology

基　　金：河北省中医药管理局科学研究课题计划项目(项目编号:2025517)。

摘　　要：目的基于肠道菌群、性激素水平、临床妊娠率探究毓麟珠汤剂联合西药治疗多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕症的临床效果。方法回顾性分析2021年5月至2022年5月唐山市妇幼保健院98例PCOS不孕症患者,根据治疗方式分为对照组、研究组,各49例,对照组予以常规西药治疗,研究组予以毓麟珠汤剂联合常规西药治疗,均治疗3个月。比较两组治疗效果、不良反应、治疗前后肠道菌群、性激素[雌二醇(E_(2))、促卵泡激素(FSH)、促黄体生成素(LH)]、子宫内膜容受性指标[子宫内膜厚度(ED)、子宫动脉阻力指数(RI)、搏动指数(PI)],治疗结束后随访1年,比较两组临床妊娠率。结果与对照组总有效率(75.51%)比较,研究组(91.84%)明显提高(P<0.05);治疗1个月、3个月后,研究组肠杆菌、肠球菌数量、血清LH、FSH水平、RI、PI低于对照组,双歧杆菌、乳酸杆菌数量、E_(2)水平、ED高于对照组;两组治疗期间不良反应发生率比较,差异无统计学意义(P>0.05);研究组妊娠成功率(59.57%)高于对照组(37.78%)(P<0.05)。结论毓麟珠汤剂联合常规西药治疗PCOS不孕症的疗效显著,能明显改善患者肠道菌群紊乱及性激素水平,提高临床妊娠率。Objective To explore the clinical effect of Yulinzhu decoction combined with western medicine in the treatment of polycystic ovary syndrome(PCOS)infertility based on intestinal flora,sex hormone levels,and clinical pregnancy rate.Methods A retrospective study was conducted on 98 patients with PCOS infertility from Tangshan Maternal and Child Health Hospital from May 2021 to May 2022,who were divided into a control group and a study group according to different treatment methods,with 49 cases in each group.The control group received conventional western medicine treatment,while the study group received Yulinzhu decoction combined with conventional western medicine,and both groups were treated for 3 months.The therapeutic effect,adverse reactions,intestinal flora,sex hormones[luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E_(2))],endometrial receptivity indexes[endometrial thickness(ED),uterine artery resistance index(RI),and pulse index(PI)]of the two groups were compared before and after treatment.Clinical pregnancy rates were compared between the two groups at 1-year follow-up after the end of treatment.Results Compared with the control group(75.51%),the total effective rate of the study group(91.84%)was significantly increased(P<0.05).After 1 month and 3 months of treatment,the number of enterobacter and enterococcus,serum LH and FSH levels,RI and PI in the study group was lower than that in the control group,and the number of lactobacillus and bifidobacterium,E_(2) level,ED was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The pregnancy success rate in the study group(59.57%)was higher than that in the control group(37.78%)(P<0.05).Conclusion The Yulinzhu decoction combined with western medicine has significant therapeutic effect on PCOS infertility,which can significantly improve the intestinal flora disorder and sex hormone levels in patients,and increase the clinical pregnancy rate.

关 键 词：多囊卵巢综合征 不孕症 毓麟珠汤剂 肠道菌群 性激素 临床妊娠率 

分 类 号：R781.6[医药卫生—口腔医学]