抗抑郁药物联合埃索美拉唑、莫沙必利治疗难治性反流性食管炎的疗效  

Efficacy of antidepressant drugs combined with esomeprazole and mosapride in the treatment of refractory reflux esophagitis

作　　者：夏梅青 祝宇娇 XIA Mei-qing;ZHU Yu-jiao(Department of Spleen and Stomach Diseases,Wuhan Jiangxia District Hospital of Traditional Chinese Medicine,430200Wuhan,Hubei,China)

机构地区：[1]武汉市江夏区中医医院脾胃病科,湖北武汉430200

出　　处：《临床消化病杂志》2025年第1期16-19,共4页Chinese Journal of Clinical Gastroenterology

摘　　要：[目的]观察抗抑郁药物联合埃索美拉唑、莫沙必利治疗难治性反流性食管炎的效果。[方法]将难治性反流性食管炎患者86例。按照治疗方法的不同,分成对照组(43例)与干预组(43例)。对照组使用埃索美拉唑+莫沙必利治疗,干预组在此基础上联合使用抗抑郁药物氟哌噻吨美利曲辛治疗,对比2组食管炎胃镜分级情况、负面心理评分及胃肠功能指标。[结果]①干预组患者治疗8周后的食管炎胃镜分级正常比例明显增高,B级、C级比例明显降低(P<0.05),但组间差异无统计学意义(P>0.05)。②治疗8周后2组患者的HAMA、HAMD评分均明显减小,其中干预组评分值低于对照组(P<0.05)。③治疗8周后2组患者的胃动素、胃泌素水平均明显增高,其中干预组测定值高于对照组(P<0.05)。[结论]针对难治性反流性食管炎患者,使用抗抑郁药物联合埃索美拉唑、莫沙必利的疗效更好,有助于改善心理状态、促进胃肠功能恢复,值得推广。[Objective]To observe the effect of antidepressant drugs combined with esomeprazole and mosapride in the treatment of refractory reflux esophagitis.[Methods]A retrospective analysis was conducted on 86patients with refractory reflux esophagitis.According to different treatment methods,there were 43cases in the control group and 43cases in the intervention group.The control group was treated with esomeprazole+mosapride,and the intervention group was treated with flupirtine melitrexin combined with this treatment and the gastroscopic grading of esophagitis,negative psychological score and gastrointestinal function index were compared.[Results]①The proportion of normal esophagitis gastroscopy grading was significantly higher and the proportion of grade B and C was significantly lower in both groups after 8 weeks of treatment(P<0.05),but the difference between groups was not statistically significant(P>0.05).②The HAMA and HAMD scores of patients in both groups were significantly reduced after 8 weeks of treatment,of which the score value in the intervention group was lower than that in the control group(P<0.05).③After 8weeks of treatment,the levels of gastrin and gastrin were significantly higher in both groups,and the measured values in the intervention group were higher than those in the control group(P<0.05).[Conclusion]For patients with refractory reflux esophagitis,the use of antidepressant drugs combined with esomeprazole and mosapride has better efficacy and helps improve psychological status and promote recovery of gastrointestinal function,which is worth promoting.

关 键 词：难治性反流性食管炎 抗抑郁药物 心理状态 胃肠功能 

分 类 号：R571[医药卫生—消化系统]