Modular Access to Chiral 1,3-Substituted Fragments via Nickel-Catalyzed Arylboration Reaction  

作　　者：Yang Bao Tong Yao Weiyu Kong Yangyang Li Ying Fu Dong Wu Guoyin Yin 

机构地区：[1]The Institute for Advanced Studies,Wuhan University,Wuhan,Hubei,430072 China [2]College of Arts and Sciences,Northeast Agricultural University,Harbin,Heilongjiang,150030 China

出　　处：《Chinese Journal of Chemistry》2025年第3期261-267,共7页中国化学(英文版)

基　　金：supported by Guangdong Basic and Applied Basic Research Foundation(2024A1515011689).

摘　　要：Chiral 1,3-substituted fragments are ubiquitous in pharmaceutical molecules and natural products,prompting the development of numerous methods to access these structures.Nonetheless,devising synthetic routes for complex chiral architectures in practical applications typically demands years of expertise.Herein,we developed a nickel-catalyzed enantioselective migratory arylboration reaction of allylboronic esters using a chiral 1,2-diamine ligand,yielding a range of chiral 1,3-bis(boronates)with high enantioselectivity.The protocol is characterized by its use of commercially available substrates,mild reaction conditions,user-friendly procedures,and a broad substrate compatibility.Moreover,we demonstrate the practicality and application potential of this reaction by synthesizing several key drug intermediates.

关 键 词：ALKENES Nickel Chiral 1 3-bis(boronates) Chain-walking Carboboration ENANTIOSELECTIVITY 

分 类 号：O62[理学—有机化学]