静脉注射吲哚菁绿导航胃癌根治术的单臂开放前瞻性研究  

An open-arm prospective study of intravenous indocyanine green guided radical gastrectomy for gastric cancer

作　　者：艾世超 孙艺文 宋鹏[1] 沈晓菲[1] 刘颂[1] 孙锋 陆晓峰[1] 王萌[1] 管文贤[1] Ai Shichao;Sun Yiwen;Song Peng;Shen Xiaofei;Liu song;Sun Feng;Lu Xiaofeng;Wang Meng;Guan Wenxian(Division of Gastric Surgery,Department of General Surgery,Nanjing Drum Tower Hospital,the Affiliated Hospital of Medical School,Nanjing University,Nanjing Jiangsu Province 210008,China)

机构地区：[1]南京大学医学院附属鼓楼医院胃外科,南京210008

出　　处：《中华普外科手术学杂志(电子版)》2025年第2期166-169,共4页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：国家自然科学基金(82172645);南京市医学科技发展项目一般性课题(YKK21078);江苏省自然科学基金青年基金(BK20210022);南京鼓楼医院临床研究专项资金(2021-LCYJ-MS-09)。

摘　　要：目的探讨静脉注射吲哚菁绿导航手术在胃癌根治术中的安全性和有效性。方法纳入9例接受静脉吲哚菁绿给药后导航胃癌根治术患者入组,所有患者均实施标准的D2淋巴结清扫以及标本淋巴结分拣。吲哚菁绿注射时间分别为术前0.5h、术前4h和术前12h。对围手术期指标、肿瘤及淋巴结成像效果、肿瘤及淋巴结与周围组织信倍比、各站淋巴结分拣数目及总数目进行分析。结果纳入患者平均手术时间为(206.7±33.1)min,术中出血量为(161.1±48.6)ml,术后住院天数(10.1±1.8)d。9例患者均无严重并发症发生。三个时间点均能实现肿瘤及淋巴结的成像,0.5h肿瘤与正常胃黏膜组织产生最高信倍比(2.5±0.4),12h淋巴结与周围组织产生最高信倍比(1.9±0.6)。淋巴结总清扫数目为(74.0±29.2)枚。结论静脉吲哚菁绿导航胃癌根治术有效。Objective To investigate the safety and efficacy of intravenous indocyanine green navigation surgery in radical gastrectomy.Methods Nine patients receiving intravenous indocyanine green guided radical gastrectomy were enrolled.All patients underwent standard D2 lymph node dissection and lymph node sorting.Indocyanine green was injected at 0.5h,4h and 12h before surgery,respectively.Perioperative indexes,imaging effects of tumor and lymph nodes,the ratio of tumor and lymph nodes to surrounding tissue,the number of lymph nodes sorted at each station and the total number were analyzed.Measurement data with normal distribution were represent as(Mean±SD).Results The mean operation time of the included patients was(206.7±33.1)min,the intraoperative blood loss was(161.1±48.6)ml,and the postoperative hospital stay was(10.1±1.8)d.None of the 9 patients had serious complications.The imaging of tumor and lymph nodes could be achieved at all three time points.The highest ratio of tumor to normal gastric mucosal tissue was(2.5±0.4)at 0.5h,and the highest ratio of lymph node to surrounding tissue was(1.9±0.6)at 12h.The total number of lymph nodes was(74.0±29.2).Conclusions Intravenous indocyanine green navigation radical gastrectomy is effective.

关 键 词：胃肿瘤 胃癌根治术 吲哚菁绿 肿瘤示踪 淋巴结示踪 

分 类 号：R73[医药卫生—肿瘤]