Efficacy of adjunctive systemic or local antibiotic therapy in peri-implantitis:a systematic review and meta-analysis of randomized controlled clinical trials  

作　　者：Yifan LU Siqi BAO Hongke LUO Qianming CHEN Misi SI 

机构地区：[1]Stomatology Hospital,School of Stomatology,Zhejiang University School of Medicine,Zhejiang Provincial Clinical Research Center for Oral Diseases,Key Laboratory of Oral Biomedical Research of Zhejiang Province,Cancer Center of Zhejiang University,Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province,Hangzhou 310000,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第2期145-157,共13页浙江大学学报(英文版)B辑(生物医学与生物技术)

基　　金：supported by the Fundamental Research Funds for the Central Universities(No.2023QZJH59/226-2023-00155);the National Natural Science Foundation of China(Nos.82370990 and 82201051);the Medical Health Science and Technology Project of Zhejiang Provincial Health Commis-sion(No.WKJ-ZJ-2335);the Innovative Talent of Zhejiang Provincial Health Commission,the Zhejiang“Xinmiao”Tal-ents Program(No.2023R401211),China.

摘　　要：This systematic review and meta-analysis considered the results of randomized controlled clinical trials(RCTs)to evaluate the efficacy of systemic or local antibiotic therapy in peri-implantitis.Two independent authors screened publications from three electronic databases to include RCTs meeting all the inclusion and exclusion criteria.A meta-analysis was performed to evaluate the weighted mean differences in survival rate(SR)and changes in pocket probing depth(PPD),bone level(BL),and clinical attachment level(CAL).The study cohorts were defined as antibiotic and control groups with subgroups for analysis.Seven studies including 309 patients(390 implants)were considered.Within the limitations of this review,patients in the antibiotic groups exhibited significant improvements in PPD.Subgroup analysis indicated that the administration of systemic antibiotics or the use of antibiotics in non-surgical treatments did not result in a significant alteration in BL.It was established that the addition of antibiotics can ameliorate PPD and SR in the treatment of peri-implantitis,whether through surgical or non-surgical approaches,and also shows moderate performance regarding BL and CAL.Considering the lack of application of new technologies in the control group and the hardship of assessing the potential risks of antibiotics,careful clinical judgment is still necessary.

关 键 词：PERI-IMPLANTITIS Dental implant Oral medicine MICROBIOLOGY Disease management META-ANALYSIS 

分 类 号：R73[医药卫生—肿瘤]