局部硬化注射联合口服普萘洛尔治疗婴幼儿眶周血管瘤的疗效对比  

Comparison and analysis of the efficacy and influencing factors of local sclerotherapy injection and combined oral propranolol treatment for periocular infantile hemangioma

作　　者：韩文良 赵谦 龚相安 李志宇 王璐颖 付聪 毕见海 霍然 HAN Wenliang;ZHAO Qian;GONG Xiang'an;LI Zhiyu;WANG Luying;FU Cong;BI Jianhai;HUO Ran(Department of Plastic Surgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院整形美容外科,山东济南250021 [2]山东省公共卫生临床中心整形创面修复外科,山东济南250021

出　　处：《中国美容整形外科杂志》2025年第2期84-89,I0008,共7页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的对比两种不同方案治疗婴幼儿眶周血管瘤的临床疗效及预后的相关因素。方法回顾性分析自2018—2022年,山东第一医科大学附属省立医院整形美容外科共收治78例眶周婴幼儿血管瘤患儿,按治疗方法分为2组,A组(47例)采用经服普萘洛尔联合局部注射曲安奈德及聚桂醇;B组(31例)仅瘤体内局部多点注射曲安奈德及聚桂醇。比较两组患儿治疗时间、瘤体范围、体积及血流信号等。结果A组患儿治疗时间及封闭治疗次数少于B组;两组患儿开始治疗的年龄、血管瘤分型、瘤体的体积、血流信号对治疗效果的影响进行比较,差异有统计学意义(P<0.05)。结论口服普萘洛尔联合局部注射曲安奈德和聚桂醇治疗婴幼儿眶周血管瘤可缩短疗程、减少注射次数。单独使用曲安奈德和聚桂醇注射也是安全有效的替代方法。Objective To retrospectively compare the clinical efficacy and prognostic related factors of two different regimens in the treatment of periorbital infantile hemangiomas.Methods A retrospective analysis was conducted on a total of 78 children with periorbital infantile hemangiomas who were admitted to the Department of Plastic Surgery in Shandong Provincial Hospital Affiliated to Shandong First Medical University from 2018 to 2022.They were grouped according to the treatment methods.In Group A,oral propranolol combined with local injection of triamcinolone acetonide and lauromacrogol was used;in Group B,only local multi-point injection of triamcinolone acetonide and lauromacrogol within the tumor was performed.Compare the treatment time,tumor range,volume and blood flow signals of the two groups of children.Results The treatment time and the number of sclerotherapy sessions in Group A were less than those in Group B.When comparing the age at the start of treatment,the classification of hemangiomas,the volume of the tumor,and the impact of blood flow signals on the treatment effect between the two groups of children,the differences were statistically significant(P<0.05).Conclusion Combined treatment with oral propranolol and local injection of triamcinolone acetonide and polyvinyl alcohol for infantile vascular tumors around the orbital region can shorten the triamcinolone acetonide.Polyvinyl alcohol injection alone is also a safe and effective alternative method.

关 键 词：婴幼儿眶周血管瘤 普萘洛尔 曲安奈德 聚桂醇 联合治疗 

分 类 号：R739.7[医药卫生—肿瘤]