靶向白血病缺氧微环境相关药物的研究进展  

Progress of drugs targeting the hypoxic microenvironment of leukemia

作　　者：景丽娟 王慧霞 杨丽丽 李海鹰 Jing Lijuan;Wang Huixia;Yang Lili;Li Haiying(First Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou 730000,China;Department of Endocrinology,the Third People's Hospital of Gansu Province,Lanzhou 730000,China;School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,兰州730000 [2]甘肃省第三人民医院内分泌科,兰州730000 [3]甘肃中医药大学公共卫生学院,兰州730000

出　　处：《白血病.淋巴瘤》2025年第2期121-125,共5页Journal of Leukemia & Lymphoma

基　　金：“甘肃中医药大学”人才科研启动基金(2019YJRC⁃03);甘肃省青年博士基金(2021QB⁃081)。

摘　　要：白血病是一种严重危害患者生命质量的恶性增殖性肿瘤。近年来对白血病发病机制的研究不断取得新的成果,靶向白血病缺氧微环境相关药物成为研究热点,并取得了一定的进展。文章主要从缺氧微环境相关的活性氧、缺氧诱导因子、CXC趋化因子受体、血管内皮生长因子等方面,对靶向缺氧微环境治疗白血病相关药物的研究进展进行综述。Leukemia is a malignant proliferative tumor that seriously endangers the quality of life of patients.In recent years,new research achievements have been made on the pathogenesis of leukemia,and some progresses of various drugs targeting the hypoxic microenvironment of leukemia have been made.This article reviews the progress of drugs targeting hypoxia microenvironment to treat leukemia from the aspects such as reactive oxygen species associated with anoxic microenvironment,hypoxia inducible factor,CXC chemokine receptor and vascular endothelial growth factor.

关 键 词：白血病 肿瘤微环境 缺氧微环境 分子靶向治疗 

分 类 号：R73[医药卫生—肿瘤]