CircRNA-IFT80在急性脑梗死患者外周血中的表达水平及临床意义  

Expression level and clinical significance of Circ-IFT80 in peripheral blood of patients with acute cerebral infarction

作　　者：美丽 刘丹[1] 张广炜[2] MEI Li;LIU Dan;ZHANG Guangwei(Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,China;The Third Department of Neurological,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology)

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]内蒙古科技大学包头医学院第一附属医院神经内三科

出　　处：《包头医学院学报》2025年第3期72-77,共6页Journal of Baotou Medical College

基　　金：包头市科技计划项目(2020GG0212)。

摘　　要：目的:探讨环状RNA中的CircRNA-IFT80在急性脑梗死患者外周血中的表达水平及临床价值。方法:选择2021年6月至2021年12月连续收入院的急性脑梗死患者39例为研究组,选取同一医院相同时期的就诊或体检人群44例为对照组。采用实时荧光定量PCR法检测CircRNA-IFT80水平,分析基本资料和CircRNA-IFT80表达水平与急性脑梗死的相关性。运用ROC曲线分析CircRNA-IFT80在急性脑梗死中的价值。结果:研究组循环血中Circ RNA-IFT80的表达低于健康对照组(P<0.001)。急性脑梗死的发生与年龄、性别、收缩压、舒张压、总胆固醇、高密度脂蛋白、高血压史、吸烟史、饮酒史、CircRNA-IFT80的表达有显著性相关。CircRNA-IFT80的表达量为急性脑梗死发病的保护性因素。结论:Circ RNA-IFT80在脑梗死中表达差异,Circ RNA-IFT80可在急性脑梗死的发生发展中发挥潜在作用。Objective:To investigate the expression level and clinical value of CircRNA-IFT80 in peripheral blood of patients with acute cerebral infarction.Methods:From June 2021 to December 2021,39 patients with acute cerebral infarction who were admitted to the hospital continuously were selected as the study group,and 44 patients who visited or underwent physical examination in the same hospital during the same period were selected as the control group.The level of CircRNA-IFT80 was detected by real-time fluorescence quantitative PCR,and the correlation between basic data and CircRNA-IFT80 expression level and acute cerebral infarction was analyzed.ROC curve was used to analyze the value of CircRNA-IFT80 in acute cerebral infarction.Results:The expression of Circ RNA-IFT80 in circulating blood of the study group was lower than that of the healthy control group(P<0.001).The incidence of acute cerebral infarction was significantly correlated with age,sex,systolic blood pressure,diastolic blood pressure,total cholesterol,high density lipoprotein,hypertension history,smoking history,drinking history and CircRNA-IFT80 expression.The expression of CircRNA-IFT80 was a protective factor for acute cerebral infarction.Conclusion:The expression of Circ RNA-IFT80 is different in cerebral infarction,and Circ RNA-IFT80 may play a potential role in the occurrence and development of acute cerebral infarction.

关 键 词：环状RNA CircRNA-IFT80 急性脑梗死 

分 类 号：R74[医药卫生—神经病学与精神病学]