多发性骨髓瘤骨病发病的危险因素  

Risk factors of multiple myeloma bone disease

作　　者：于明罡 厉吉霞[2] YU Minggang;LI Jixia(Binzhou Medical University,Yantai 264003,Shandong,P.R.China;Department of Laboratory Medicine,Yantaishan Hospital,Yantai 264000,Shandong,P.R.China)

机构地区：[1]滨州医学院,山东烟台264003 [2]烟台市烟台山医院检验科,山东烟台264000

出　　处：《滨州医学院学报》2025年第1期30-34,共5页Journal of Binzhou Medical University

摘　　要：目的探讨引起多发性骨髓瘤骨病发病的危险因素。方法将136例初诊多发性骨髓瘤患者作为研究对象,其中115例患者为多发性骨髓瘤骨病组,21例为非骨病对照组。收集两组患者的一般临床资料、实验室检验结果、病例分型与临床分期,采用二元Logistic回归分析探讨多发性骨髓瘤骨病发病的危险因素。结果二元Logistic回归分析结果显示,性别、平均红细胞体积(mean corpuscular volume,MCV)、血浆纤维蛋白原(fibrinogen,FIB)、血肌酐(serum creatinine,Scr)、血清钙(Ca)、血清校正Ca及血清胱抑素C(cystatin C,CysC)是影响多发性骨髓瘤骨病发病的独立相关因素(P<0.05)。其中性别、血清Ca、血清校正Ca及CysC为危险因素(OR>1),而MCV、FIB、Scr为保护因素(OR<1)。ROC曲线分析结果显示,血清Ca、血清校正Ca、Ki67阳性细胞数联合预测多发性骨髓瘤骨病的AUC值高于三者单独诊断时的AUC值。结论血清Ca、血清校正Ca、Ki67阳性细胞数对多发性骨髓瘤骨病具有较好的诊断预测价值。Objective To explore the risk factors for the occurrence of multiple myeloma bone disease(MBD).Methods A total of 136 newly diagnosed patients with multiple myeloma(MM)were selected as the study subjects.All subjects were divided into the MBD group(115 cases)and the control group(21 MM cases without bone disease).The clinical data,laboratory tests,case classification,and clinical stages of two groups were collected and the risk factors of MBD were analyzed by multivariate Logistic regression.Results The results of binary logistic regression analysis showed that gender,mean corpuscular volume(MCV),fibrinogen(FIB),serum creatinine(Scr),serum calcium,serum corrected calcium,and Cystatin C(CysC)were independent predictors of the incidence of MBD.And gender,serum calcium,serum corrected calcium,CysC were risk factors(OR>1),while MCV,FIB,Scr were protective factors(OR<1).The results of ROC curve analysis showed that the AUC of serum calcium combined with serum corrected calcium and the positive cells of Ki67 for predicting MBD was higher than those of single marker tests.Conclusion The levels of serum calcium,serum corrected calcium,and the positive cells of Ki67 are of good application value in clinical prediction and diagnosis of MBD.

关 键 词：多发性骨髓瘤 多发性骨髓瘤骨病 危险因素 

分 类 号：R733.3[医药卫生—肿瘤]