血清ANXA2、FGFR2在急性胰腺炎病情严重程度及预后评估中的应用价值  

Application value of serum ANXA2 and FGFR2 in the evaluation of severity and prognosis of acute pancreatitis

作　　者：许德俊[1] 张祎 谢辉[1] 付生弟[1] 向昌光子 祝鹏 XU Dejun;ZHANG Yi;XIE Hui;FU Shengdi;XIANG Changguangzi;ZHU Peng(Department of Internal Medicine,Affiliated Hospital of Hubei Three Gorges Vocational and Technical College,Yichang,Hubei 443000,China;Department of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China)

机构地区：[1]湖北三峡职业技术学院附属医院内科,湖北宜昌443000 [2]华中科技大学同济医学院附属协和医院消化内科,湖北武汉430022

出　　处：《检验医学与临床》2025年第6期721-725,731,共6页Laboratory Medicine and Clinic

基　　金：湖北省卫生健康委员会科研项目(WJ2019M147)。

摘　　要：目的探讨血清膜联蛋白A2(ANXA2)、成纤维细胞生长因子受体2(FGFR2)在急性胰腺炎病情严重程度及预后评估中的应用价值。方法选取2021年6月至2023年6月湖北三峡职业技术学院附属医院收治的148例急性胰腺炎患者作为病例组,根据病情严重程度将其分为轻度组43例、中度组60例和重度组45例;另选取同期在湖北三峡职业技术学院附属医院体检健康的志愿者148例为对照组。收集所有研究对象的临床资料。采用酶联免疫吸附试验检测血清ANXA2、FGFR2水平。绘制受试者工作特征(ROC)曲线分析血清ANXA2、FGFR2对急性胰腺炎预后的评估价值。采用多因素Logistic回归分析急性胰腺炎预后不良的影响因素。结果与对照组相比,病例组血清ANXA2水平显著升高,FGFR2水平显著降低,差异均有统计学意义(P<0.05)。与轻度组相比,中度组和重度组血清ANXA2水平显著升高,FGFR2水平显著降低,差异均有统计学意义(P<0.05);与中度组相比,重度组血清ANXA2水平显著升高,FGFR2水平显著降低,差异均有统计学意义(P<0.05)。随访结果显示,预后良好组106例,预后不良组42例。与预后良好组相比,预后不良组甘油三酯、ANXA2水平显著升高,FGFR2水平显著降低,差异均有统计学意义(P<0.05)。ROC曲线结果显示,血清ANXA2、FGFR2联合评估急性胰腺炎预后不良的曲线下面积(AUC)显著大于血清ANXA2、FGFR2单独评估的AUC(Z=2.084、2.824,P=0.037、0.005)。多因素Logistic回归分析结果显示,甘油三酯≥2.29 mmol/L、ANXA2≥16.53 ng/mL为急性胰腺炎预后不良的危险因素(P<0.05),FGFR2≥27.003 ng/mL是急性胰腺炎预后不良的保护因素(P<0.05)。结论急性胰腺炎患者血清ANXA2水平升高,FGFR2水平降低,二者与病情密切有关,可以作为急性胰腺炎预后评估的生物学指标。Objective To explore application value of serum annexin A2(ANXA2),fibroblast growth factor receptor 2(FGFR2)in the assessment of severity and prognosis of acute pancreatitis.Methods A total of 148 patients with acute pancreatitis admitted to the Affiliated Hospital of Hubei Three Gorges Vocational and Technical College from June 2021 to June 2023 were selected as the case group,which were divided into mild group with 43 cases,moderate group with 60 cases and severe group with 45 cases according to the severity of the disease.Another 148 healthy volunteers in the Affiliated Hospital of Hubei Three Gorges Vocational and Technical College were selected as the control group.Clinical data of all research objects were collected.Serum ANXA2 and FGFR2 levels were detected by enzyme-linked immunosorbent assay.Receiver operating characteristic(ROC)curve was drawn to evaluate the prognostic value of serum ANXA2 and FGFR2 in acute pancreatitis.Multivariate Logistic regression was used to analyze the factors affecting the poor prognosis of acute pancreatitis.Results Compared with control group,the serum ANXA2 level in the case group was significantly increased and the serum FGFR2 level was significantly decreased,with statistically significant differences(P<0.05).Compared with the mild group,serum ANXA2 level in the moderate group and the severe group was significantly increased,and FGFR2 level was significantly decreased,with statistically significant differences(P<0.05).Compared with the moderate group,serum ANXA2 level in the severe group was significantly increased and FGFR2 level was significantly decreased,with statistically significant differences(P<0.05).The follow-up results showed that there were 106 cases in good prognosis group and 42 cases in poor prognosis group.Compared with the good prognosis group,the levels of triglyceride and ANXA2 in the poor prognosis group were significantly increased,and FGFR2 levels were significantly decreased,with statistically significant differences(P<0.05).ROC curve results showed

关 键 词：急性胰腺炎 膜联蛋白A2 成纤维细胞生长因子受体2 病情 预后 

分 类 号：R576[医药卫生—消化系统]