纤维蛋白原在消化道恶性肿瘤中的研究进展  

Research progress of fibrinogen in malignant tumors of the digestive tract

作　　者：陈付群 刘涛[1] 杨占花(综述) 陈兆云(审校)[1] CHEN Fuqun;LIU Tao;YANG Zhanhua;CHEN Zhaoyun(Medical Laboratory Center,the First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China)

机构地区：[1]新疆医科大学第一附属医院医学检验中心,新疆乌鲁木齐830054

出　　处：《检验医学与临床》2025年第6期860-864,共5页Laboratory Medicine and Clinic

摘　　要：纤维蛋白原(FIB)是相对分子质量为340×10^(3)的糖蛋白,主要在肝细胞中合成,是凝血系统重要的组成成分,参与机体凝血反应和组织修复过程。该文在回顾近几年国内外研究进展的基础上总结了FIB作为无创指标在消化道恶性肿瘤发生发展过程中的研究现状,重点讨论了FIB在常见消化道恶性肿瘤的诊断、治疗、肿瘤进展及预后预测中所扮演的角色,这对消化道恶性肿瘤发病机制、疗效评估、个性化治疗等方面的深入研究尤为重要。虽然研究证实FIB与消化道恶性肿瘤发生、发展密切相关,然而目前的研究主要聚焦在消化道恶性肿瘤预后预测以及早期筛查、早期诊断等方面,在肿瘤良恶性鉴别、早(或晚)期并发症等层面的研究相对较少,未来需要学者们进一步探索。Fibrinogen(FIB)is a glycoprotein with molecular weight of 340×10^(3),which is mainly synthesized in hepatocytes,and it is an important component of coagulation system and participates in the process of blood coagulation and tissue repair.On the basis of reviewing the research progress at home and abroad in recent years,this paper summarizes the research status of FIB as a non-invasive maker in the occurrence and development of digestive tract malignant tumors,and focuses on the role of FIB in the diagnosis,treatment,tumor progression and prognosis of common digestive tract malignant tumors,which is particularly important for the in-depth study of the pathogenesis,curative effect evaluation and personalized treatment of digestive tract malignant tumors.Studies have confirmed that FIB is closely related to the occurrence and development of digestive tract malignant tumors.However,the current research mainly focuses on prognosis prediction,early screening and early diagnosis of digestive tract malignant tumors.There are relatively few studies on the differentiation of benign and malignant tumors and early(or late)complications,which need to be further explored by scholars in the future.

关 键 词：纤维蛋白原 消化道 恶性肿瘤 无创指标 预测 

分 类 号：R735.34[医药卫生—肿瘤]