补虚正气粥治疗气阴两虚型弥漫大B细胞淋巴瘤化疗后癌因性疲乏45例  

Tonifying Deficiency and Zheng Qi Porridge in Treating 45 Cases of Cancer-Related Fatigue after Chemotherapy for Diffuse Large B-cell Lymphoma with Deficiency of Qi and Yin Type

作　　者：刘丽敏 付海英 翁依妹[2] 俞燕品 郑晓林 薛海华 杨柳[3] LIU Limin;FU Haiying;WENG Yimei;YU Yanpin;ZHENG Xiaolin;XUE Haihua;YANG Liu(The Third People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350108,China;Union Hospital of Fujian Medical University,Fuzhou,Fujian 350001,China;Nursing School of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian 350122,China)

机构地区：[1]福建中医药大学附属第三人民医院,福建福州350108 [2]福建医科大学附属协和医院,福建福州350001 [3]福建中医药大学护理学院,福建福州350122

出　　处：《福建中医药》2024年第12期1-4,10,共5页Fujian Journal of Traditional Chinese Medicine

基　　金：福建省教育厅中青年教师教育科研项目(JAT210206);福建省科技计划引导性项目(2022Y0040);国家大学生创新创业项目(202010393004);福建省中医药重点学科建设项目-中医血液病学(闽卫中医涵[2024]363号)。

摘　　要：目的探讨补虚正气粥对气阴两虚型弥漫大B细胞淋巴瘤(DLBCL)化疗后癌因性疲乏(CRF)的疗效。方法选取2022年3月—2023年5月在福建中医药大学附属第三人民医院血液科病房收治的气阴两虚型DLBCL化疗后癌因性疲乏患者90例,采用简单随机化法分为试验组和对照组各45例。2组均予R-CHOP化疗方案,对照组采用常规的基础护理,试验组在对照组的基础上加食补虚正气粥,早晚各1次,5 d为1个疗程,2组均治疗3个疗程。比较2组治疗前后Piper疲乏量表中国版(PFS-CV)评分,中医证候积分,血清白介素-6(IL-6)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平以及欧洲癌症研究与治疗组织生活质量核心量表(EORTC QLQ-C30)评分,并比较2组中医证候疗效。结果与治疗前比较,2组PFS-CV各维度评分、中医证候积分及血清IL-6、IL-1β、TNF-α水平均降低(P<0.05),EORTC QLQ-C30中躯体、认知、角色、社会功能、情绪、经济困难评分均升高(P<0.05),恶心呕吐、疼痛、疲劳、失眠、气促、便秘、食欲丧失、腹泻评分均降低(P<0.05);治疗后与对照组比较,试验组PFS-CV各维度评分、中医证候积分及血清IL-6、IL-1β、TNF-α水平均明显降低(P<0.05),EORTC QLQ-C30中躯体、认知、角色、社会功能、情绪、经济困难评分均明显升高(P<0.05),恶心呕吐、疼痛、疲劳、失眠、气促、便秘、食欲丧失、腹泻评分均明显降低(P<0.05)。试验组总有效率为88.89%,优于对照组的71.11%(P<0.05)。结论补虚正气粥可改善气阴两虚型DLBCL化疗后CRF患者疲乏症状,改善气阴两虚证候,降低血清炎症因子水平,提高患者生活质量,值得推广。Objective:To investigate the therapeutic effect of tonifying deficiency and Zheng Qi porridge on cancer-related fatigue(CRF)of chemotherapy for diffuse large B-cell lymphoma(DLBCL)with deficiency of qi and yin type.Methods:Ninety patients with DLBCL chemotherapy for deficiency of qi and yin type in the Department of Haematology,the Third People's Hospital of Fujian University of Traditional Chinese Medicine were selected from March 2022 to May 2023 and divided into 45 patients each in the experimental and control groups by simple randomisation method.All patients received R-CHOP chemotherapy programme,the control group was treated with conventional basic care,and the experimental group received tonifying deficiency and Zheng Qi porridge,once in the morning and once in the evening for 5 days as a treatment course,and the two groups received 3 treatment courses for a total of 15 days.Piper Fatigue Scale China Version(PFS-CV)score,traditional Chinese medicine symptom score,serum interleukin-6(IL-6),serum interleukin-1β(IL-1β),tumour necrosis factor-α(TNF-α)and European Organisation for Research and Treatment of Cancer(EORTC)Quality of Life Scale(QLQ-C30)were compared before and after treatment in the two groups,as well as the efficacy of TCM symptoms in both groups.Results:Compared with the pretreatment period,PFS-CV scores of all dimensions,TCM symptom scores,IL-6,IL-1β,and TNF-αlevels decreased in the two groups(P<0.05),the EORTC QLQ-C30 somatic,cognitive,role,social functioning,emotional and financial difficulties scores increased(P<0.05),and the scores of nausea and vomiting,pain,fatigue,insomnia,shortness of breath,and constipation,loss of appetite,and diarrhea all decreased(P<0.05).Compared with the control group,PFS-CV scores of all dimensions,TCM symptom scores,IL-6,IL-1βand TNF-αlevels were all significantly reduced(P<0.05).EORTC QLQ-C30 scores for somatic,cognitive,role,social functioning,emotional and financial difficulties all significantly increased(P<0.05),and scores of nausea and vomiting,pain

关 键 词：弥漫大B细胞淋巴瘤 化疗 癌因性疲乏 气阴两虚证 补虚正气粥 

分 类 号：R73[医药卫生—肿瘤]