口腔白斑病动物模型的研究进展  

Research Progress in Animal Models of Oral Leukoplakia

作　　者：张琦 石晶 ZHANG Qi;SHI Jing(School and Hospital of Stomatology,Shanxi Medical University,Taiyuan 030001,China;Department of Oral Medicine,Shanxi Provincial People’s Hospital,Shanxi Medical University(Shanxi Provincial Oral Health Prevention and Control Technology Innovation Center),Taiyuan 030012,China)

机构地区：[1]山西医科大学口腔医学院·口腔医院,山西太原030001 [2]山西医科大学附属山西省人民医院口腔内科(山西省口腔健康防控技术创新中心),山西太原030012

出　　处：《口腔医学研究》2025年第3期179-183,共5页Journal of Oral Science Research

基　　金：山西省卫生健康委员会项目(编号:2020TD17)。

摘　　要：口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)患者预后较差,5年生存率不足50%。为了提高生存率和预后,应在口腔潜在恶性疾患(oral potentially malignant disorders,OPMDs)阶段及早进行干预,口腔白斑病(oral leukoplakia,OLK)为最常见OPMDs,建立一个理想的OLK动物模型可以对肿瘤演变的过程有更深刻的认识。本文将对常见的OLK动物模型作一综述。Patients with oral squamous cell carcinoma(OSCC)have a poor prognosis whose 5-year survival rate is less than 50%.Early intervention in the oral potentially malignant disorders(OPMDs)stage is necessary to improve survival rate and prognosis,oral leukoplakia(OLK)is the most common OPMDs.In order to understand the process of OSCC deeply,an ideal OLK animal model is in great request.In this paper,the common animal models of OLK were reviewed.

关 键 词：口腔白斑病 口腔鳞状细胞癌 动物模型 

分 类 号：R739.8[医药卫生—肿瘤] R781.5[医药卫生—临床医学] R-332