双极性电化学用于卡马西平氧化在线质谱监测  

Paper-in-Tip Bipolar Electrolytic Electrospray Mass Spectrometry for Monitoring Carbamazepine Oxidation

作　　者：王彤 WANG Tong(School of Chemistry and Chemical Engineering,Xi an Shiyou University,Xi an 710065,China)

机构地区：[1]西安石油大学化学化工学院,陕西西安710065

出　　处：《云南化工》2025年第3期73-77,共5页Yunnan Chemical Technology

摘　　要：建立了一种新型源内纸基质双极电化学-纸喷雾质谱分析方法,用于原位监测卡马西平氧化机理。将涂有碳纳米管的三角形导电纸纳入移液枪头尖端,作为纸喷雾离子源,用于双极电极电化学池,施加高压进行电化学-质谱分析,从而实现卡马西平氧化反应的在线监测。结果表明,在电极材料为碳纳米管、喷雾溶剂为甲醇、施加4.5 kV高压的条件下,可明显检测到卡马西平在电化学反应下所生成的一系列中间体、最终产物,以及它们在反应过程中随时间的变化趋势,从而推测卡马西平电化学氧化过程中的反应机理。A novel in-source paper matrix bipolar electrochemics-paper spray mass spectrometry method was established to monitor carbamazepine oxidation mechanism in situ.In this method,triangular conductive paper coated with carbon nanotubes was incorporated into the tip of pipetting gun,which could be used as both a paper spray ion source and a bipolar electrode electrochemical cell for electrochemic-mass spectrometry.The real-time on-line monitoring of carbamazepine oxidation was realized.The results show that a series of intermediates and products generated by carbamazepine in electrochemical reaction can be detected obviously under the condition of carbon nanotubes as electrode material,methanol as spray solvent and 4.5kV high pressure,and their change trend with time during the reaction process,so as to speculate the reaction mechanism of carbamazepine in electrochemical oxidation process.

关 键 词：质谱 卡马西平 电化学 纸喷雾 氧化机理 在线监测 

分 类 号：O657.63[理学—分析化学]