Chiral drugs:Sources,absolute configuration identification,pharmacological applications,and future research trends  

The two authorsto this work and share first authorship.

作　　者：Shou-jiao Peng Yu-ying Zhu Chun-ying Luo Pei Zhang Fei-yun Wang Rui-xiang Li Guo-qiang Lin Jian-ge Zhang 

机构地区：[1]Research Center of Chiral Drugs,Innovation Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China

出　　处：《LabMed Discovery》2024年第1期40-48,共9页检验医学发现(英文)

基　　金：supported by the Shanghai Science and Technology Development Fund from the Central Leading Local Government(No.YDZX20223100001004);the Organizational Key Research and Development Program of SHUTCM(No.2023YZZ01);the Shanghai Pujiang Program(No.23PJ1411200).

摘　　要：Chirality is one of the essential attributes of nature.Chiral drugs refer to a class of drugs containing chiral centers,and the molecular stereo-structures of their enantiomers are non-superimposable mirror images of each other.Sixty percent of commonly used drugs,including those from traditional Chinese medicine(TCM),are chiral.Developing a single enantiomer with high efficiency and low toxicity has drawn considerable attention due to significant differences in pharmacological activities,metabolic processes,and toxicity exhibited by the enantiomers of chiral drugs.This review concisely summarizes chiral drugs,including their sources,absolute configuration identification,pharmacological applications,and future research trends,particularly in TCM.

关 键 词：Chiral drug ENANTIOMER Traditional Chinese medicine(TCM) Pharmacological application 

分 类 号：O62[理学—有机化学]