信号转导和转录活化因子3在骨肉瘤中的表达及临床意义  

Expression and Clinical Significance of Signal Transduction and Transcriptional Activation Factor 3 in Osteosarcoma

作　　者：但丹[1] 陈凤霞 嘉颖 浦飞飞 DAN Dan;CHEN Fengxia;JIA Ying;PU Feifei(Wuhan No.1 Hospital,Wuhan 430022,China;Zhongnan Hospital of Wuhan University,Wuhan 430071,China;The First Clinical School,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]武汉市第一医院,武汉430022 [2]武汉大学中南医院 [3]华中科技大学同济医学院第一临床学院

出　　处：《中国中医骨伤科杂志》2025年第2期29-33,共5页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：国家自然科学基金项目(82474545,82274559,81904231);中国博士后科学基金项目(2024T170247,2024M750820);湖北省自然科学基金项目(2024AFB1011);武汉市自然科学基金探索计划(晨光计划)项目(2024040801020366)。

摘　　要：目的:探讨骨肉瘤中信号转导和转录活化因子3(STAT3)蛋白表达水平及临床意义。方法:用免疫组织化学法检测36例骨肉瘤标本中STAT3蛋白表达水平,分析STAT3表达水平与患者临床病理特征的相关性。采用Kaplan-Meier生存分析探讨STAT3表达水平与骨肉瘤患者预后的相关性。结果:STAT3蛋白阳性反应主要定位于细胞质,36例骨肉瘤肿瘤组织中STAT3高表达31例(86.11%),癌旁组织中STAT3高表达13例(36.11%),差异有统计学意义(P<0.05);STAT3高表达与患者Enneking分期高、化疗反应较差、肺转移发生率高、总生存期短相关,差异有统计学意义(P<0.05)。结论:STAT3在骨肉瘤中高表达,其表达强度与患者不良预后正相关。Objective:To investigate the expression and its clinical significance of signal transduction and transcriptional activating factor 3(STAT3)protein in osteosarcoma.Methods:The expression of STAT3 protein in 36 osteosarcoma samples was detected by immunohistochemistry,and the clinicopathological features of the patients were analyzed.Kaplan-Meier survival analysis was used to investigate the correlation between STAT3 expression and prognosis of patients with osteosarcoma.Results:The positive reaction of STAT3 protein was mainly located in cytoplasm.STAT3 was overexpressed in 31 cases(86.11%)and 13 cases(36.11%)of 36 cases of osteosarcoma(P<0.05).Patients with high STAT3 expression had high Enneking stages,poor chemotherapy response,high incidence of lung metastasis and short overall survival(P<0.05).Conclusion:STAT3 protein is highly expressed in osteosarcoma,and its expression intensity is positively correlated with poor prognosis.

关 键 词：骨肉瘤 信号转导和转录活化因子3 免疫组织化学法 生存分析 临床预后 

分 类 号：R73[医药卫生—肿瘤]